A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
| Autor: | Nora Fernandez-Jimenez, Ruby Fore, Ariadna Cilleros-Portet, Johanna Lepeule, Patrice Perron, Tuomas Kvist, Fu-Ying Tian, Corina Lesseur, Alexandra M. Binder, Manuel Lozano, Jordi Martorell-Marugán, Yuk J. Loke, Kelly M. Bakulski, Yihui Zhu, Anne Forhan, Sara Sammallahti, Todd M. Everson, Jia Chen, Karin B. Michels, Thalia Belmonte, Pedro Carmona-Sáez, Jane Halliday, M. Daniele Fallin, Janine M. LaSalle, Jorg Tost, Darina Czamara, Mariana F. Fernández, Antonio Gómez-Martín, Jeffrey M. Craig, Beatriz Gonzalez-Alzaga, Rebecca J. Schmidt, John F. Dou, Evelyne Muggli, Marina Lacasaña, Martine Vrijheid, Carmen J. Marsit, Margaret R. Karagas, Katri Räikkönen, Luigi Bouchard, Barbara Heude, Loreto Santa-Marina, Mariona Bustamante, Marie-France Hivert, Jose Ramon Bilbao |
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| Přispěvatelé: | Child and Adolescent Psychiatry / Psychology, Department of Psychology and Logopedics, Developmental Psychology Research Group |
| Rok vydání: | 2021 |
| Předmět: |
Risk
Epigenomics 515 Psychology Placenta Medicine (miscellaneous) Birth-weight Mothers Cohort profile Reproductive health and childbirth Associations General Biochemistry Genetics and Molecular Biology Exposure Body Mass Index SDG 3 - Good Health and Well-being Pregnancy Genetics research Genetics 2.1 Biological and endogenous factors Humans Obesity Variant Gain Aetiology Child Newborns Nutrition Pediatric Human Genome Infant Newborn Child Health Infant Perinatal Period - Conditions Originating in Perinatal Period DNA Methylation Newborn Good Health and Well Being Female General Agricultural and Biological Sciences |
| Zdroj: | Communications biology, vol 5, iss 1 Communications Biology, 5(1):1313. Springer Nature |
| ISSN: | 2399-3642 |
| Popis: | Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The overall aim of the present work is to investigate the association of ppBMI with epigenomewide placental DNA methylation (DNAm) in 10 studies from the PACE consortium, amounting to 2631 mother-child pairs. We identify 27 CpG sites at which we observe placental DNAm variations of up to 2.0% per 10 ppBMI-unit. The CpGs that are differentially methylated in placenta do not overlap with CpGs identified in previous studies in cord blood DNAm related to ppBMI. Many of the identified CpGs are located in open sea regions, are often close to obesity-related genes such as GPX1 and LGR4 and altogether, are enriched in cancer and oxidative stress pathways. Our findings suggest that placental DNAm could be one of the mechanisms by which maternal obesity is associated with metabolic health outcomes in newborns and children, although further studies will be needed in order to corroborate these findings. French Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences de l'Univers (INSU) Swiss National Science Foundation (SNSF) European Commission Ministry of Science and Innovation, Spain (MICINN) Spanish Government FJC2018-036729 European Development Fund European Social Fund (ESF) |
| Databáze: | OpenAIRE |
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