Increase of brain tumor oxygenation during cervical spinal cord stimulation
| Autor: | M. Antonia Hernández, Martina Günderoth, Jesús Morera, Juan L. Pérez, Francisco Robaina, Bernardino Clavo, David Macías, Miguel Á. Caramés, Eugenio Ruiz-Egea, L. Catala |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Brain tumor Urology Electric Stimulation Therapy Astrocytoma Central nervous system disease Oxygen Consumption Glioma Humans Medicine Aged Cerebral Cortex Brain Neoplasms business.industry General Medicine Oxygenation Middle Aged Tumor Oxygenation medicine.disease Spinal cord Combined Modality Therapy Cell Hypoxia Electrodes Implanted Surgery medicine.anatomical_structure Spinal Cord Regional Blood Flow Female Radiotherapy Adjuvant Glioblastoma business Perfusion Polarography |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| ISSN: | 1547-5654 |
| Popis: | ✓ Malignant brain tumors have been shown to decrease O2 and blood flow resulting in hypoxia and low perfusion that in turn reduce radiation sensitivity and access by chemotherapeutic agents. Spinal cord stimulation (SCS) is a procedure that has been used quite successfully in the treatment of pain and ischemic syndromes. In the present study the authors applied the method and, with polarographic probes inserted in the tumor sites, measured the changes in tissue oxygenation and hypoxia in two separate tumor areas in three patients with high-grade astrocytomas. The results of the SCS indicated that overall tumor oxygenation increased by 90% (from 13.2 ± 9.4 mm Hg to 25.1 ± 9.6 mm Hg; p = 0.013); the percentage of moderately hypoxic values (< 10 mm Hg) decreased by 55% (from 48.6 ± 20.1% to 22 ± 13.3%; p = 0.026); and the percentage of considerably hypoxic values (< 5 mm Hg) decreased by 45% (from 28 ± 20.3% to 15.5 ± 15%; p = 0.018). In this report the authors describe a potential novel application of SCS, and the preliminary results suggest that tumor tissue oxygenation and hypoxia are significantly improved as a result. If these findings are confirmed, the method may be applicable as an adjuvant to radiotherapy and chemotherapy regimens. |
| Databáze: | OpenAIRE |
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