Toward Physicochemical and Rheological Characterization of Different Injectable Hyaluronic Acid Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether
| Autor: | Nicola Zerbinati, Sabrina Sommatis, Raffaele Rauso, Roberto Mocchi, Giulia Grimaldi, Cristina Maccario, Marina Protasoni, Giuseppe Alonci, Maria Chiara Capillo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Diglycidyl ether
Polymers and Plastics Biocompatibility Polyethylene glycol engineering.material cross-linked HA hydrogels Dermal Fillers Article Cohesivity Cross-linked HA hydrogels Matrix structure Optical microscopic examination PEGDE Rheological properties lcsh:QD241-441 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheology lcsh:Organic chemistry matrix structure Filler (materials) Hyaluronic acid cohesivity General Chemistry optical microscopic examination rheological properties chemistry Chemical engineering 030220 oncology & carcinogenesis Self-healing hydrogels engineering |
| Zdroj: | Polymers Volume 13 Issue 6 Polymers, Vol 13, Iss 948, p 948 (2021) |
| ISSN: | 2073-4360 |
| DOI: | 10.3390/polym13060948 |
| Popis: | (1) Background: Injectable hyaluronic acid (HA) dermal fillers are used to restore volume, hydration and skin tone in aesthetic medicine. HA fillers differ from each other due to their cross-linking technologies, with the aim to increase mechanical and biological activities. One of the most recent and promising cross-linkers is polyethylene glycol diglycidyl ether (PEGDE), used by the company Matex Lab S.p.A., (Brindisi, Italy) to create the HA dermal filler PEGDE family. Over the last few years, several studies have been performed to investigate the biocompatibility and biodegradability of these formulations, but little information is available regarding their matrix structure, rheological and physicochemical properties related to their cross-linking technologies, the HA content or the degree of cross-linking. (2) Methods: Seven different injectable HA hydrogels were subjected to optical microscopic examination, cohesivity evaluation and rheological characterization in order to investigate their behavior. (3) Results: The analyzed cross-linked dermal fillers showed a fibrous “spiderweb-like” matrix structure, with each medical device presenting different and peculiar rheological features. Except for HA non cross-linked hydrogel 18 mg/mL, all showed an elastic and cohesive profile. (4) Conclusions: The comparative analysis with other literature works makes a preliminary characterization of these injectable medical devices possible. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|