Host responses to Epstein-Barr virus and cytomegalovirus infection in leprosy
| Autor: | K. Kouzoutzakoglou, Philip R. Glade, Peter L. Workman, Carol F. Sorokin, Richard J. Bonforte, Photini S. Papageorgiou |
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| Rok vydání: | 1973 |
| Předmět: |
Cellular immunity
Herpesvirus 4 Human Immunodiffusion Immunology Congenital cytomegalovirus infection Cytomegalovirus Fluorescent Antibody Technique Tuberculoid leprosy Biology Antibodies Viral Microbiology Virus Immunity hemic and lymphatic diseases Leprosy medicine Humans Antigens Viral Lepromatous leprosy Immunity Cellular Complement Fixation Tests Antibody titer medicine.disease Virology Viral Infections Infectious Diseases Immunoglobulin G Antibody Formation Parasitology |
| Zdroj: | Infection and immunity. 7(4) |
| ISSN: | 0019-9567 |
| Popis: | A study was undertaken in patients with leprosy to assess the contribution of cell-mediated immunity to the host response to Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection. Sixteen of 72 patients (22%) with lepromatous leprosy, with impaired cellular immunity, had anti-EBV titers of 1,640 or higher. Only 4 of 49 patients (8%) with tuberculoid leprosy, with intact cell-mediated immunity, attained the level of 1:640. The anti-EBV antibody titers were significantly higher in patients with lepromatous leprosy ( P ≃ 0.025). No significant differences were found in the level of anti-CMV antibody titers in patients with the two types of leprosy. The presence of high anti-EBV antibody titers in lepromatous leprosy suggests that cell-mediated immunity is a significant factor in host response to EBV infection. Host immune responses should be taken into consideration when assignment of an etiological role to EBV is based upon seroepidemiological data. |
| Databáze: | OpenAIRE |
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