Impact of serum omentin-1 concentrations on functional outcome among acute intracerebral hemorrhage patients
| Autor: | Yu-Yu Xu, Xin-Xiang Zhou, Mi Guo, Guo-Hai Zhang, Zhe-Hao Ye, Hao-Jie Guan |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Clinical Biochemistry Logistic regression GPI-Linked Proteins Biochemistry Gastroenterology Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Modified Rankin Scale Interquartile range Internal medicine Lectins medicine Humans Prognostic biomarker Acute ischemic stroke Stroke Aged Cerebral Hemorrhage Intracerebral hemorrhage business.industry Biochemistry (medical) General Medicine Recovery of Function Middle Aged medicine.disease Prognosis 030104 developmental biology Increased risk Logistic Models ROC Curve 030220 oncology & carcinogenesis Cytokines Female business Biomarkers |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 503 |
| ISSN: | 1873-3492 |
| Popis: | Reduced serum omentin-1 concentrations might be related to an increased risk for poor functional outcome after acute ischemic stroke. We intended to explore whether serum omentin-1 could be a promising prognostic biomarker for acute intracerebral hemorrhage.A total of 104 consecutive patients with hemorrhagic stroke underwent 90-day follow-up. The modified Rankin scale score2 was evaluated as worse prognosis. A multivariable logistic model was conFig.d for assessing the relationship between serum omentin-1 concentrations and functional outcome.Serum omentin-1 concentrations, with the median value of 147.9 ng/ml (interquartile range, 114.7-199.8 ng/ml), were substantially declined with rising modified Rankin scale scores (P 0.001). Serum omentin-1 concentrations147.9 ng/ml was independently related to higher risk of 90-day worse prognosis (odds ratio, 3.789; 95% confidence interval, 1.819-8.608; P = 0.018). Under receiver operating characteristic curve, an optimal value of serum omentin-1 concentrations was selected as 179.7 ng/ml, which yielded 0.88 sensitivity value and 0.70 specificity value for discriminating patients at risk of 90-day worse prognosis (area under curve, 0.82; 95% confidence interval, 0.73-0.89).Lower serum omentin-1 concentrations are closely associated with poor functional outcome after hemorrhagic stroke, substantializing serum omentin-1 as a potential prognostic biomarker for acute intracerebral hemorrhage. |
| Databáze: | OpenAIRE |
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