Use of hepadnavirus core proteins as vaccine platforms
| Autor: | Byung O. Lee, David C. Whitacre, David R. Milich |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Hepatitis B virus
Protein subunit viruses Recombinant Fusion Proteins Immunology Biology medicine.disease_cause Article law.invention Virus-like particle Antigen law Drug Discovery medicine Humans Pharmacology Vaccines Synthetic Immunogenicity Virology Hepatitis B Core Antigens Vaccines Virosome HBcAg Recombinant DNA Molecular Medicine Hepadnavirus Carrier Proteins |
| Zdroj: | Expert review of vaccines. 8(11) |
| ISSN: | 1744-8395 |
| Popis: | The first virus-like particle to be tested for use as a vaccine carrier was based on the hepatitis B virus nucleocapsid protein. This viral subunit, while not infectious on its own, is a 36-nm particle that is highly immunogenic during a natural infection. The self-assembly and high degree of immunogenicity is maintained when expressed as a recombinant protein and, moreover, can confer a high degree of immunogenicity on foreign antigens linked to the particle, either chemically or genetically. This review describes the current state of the hepadnaviral core protein as a vaccine carrier. |
| Databáze: | OpenAIRE |
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