T1-weighted functional imaging based on a contrast agent in presurgical mapping
| Autor: | Rafael Malach, Pazit Pianka, Orna Aizenstein, Ida Sivan, Dafna Ben Bashat, Michal Ziv, Gil Navon, Talma Hendler, Moshe Graif |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Gadolinium DTPA Male genetic structures media_common.quotation_subject Contrast Media Post injection Sensitivity and Specificity Young Adult Image Interpretation Computer-Assisted Preoperative Care T1 weighted Medicine Contrast (vision) Humans Radiology Nuclear Medicine and imaging media_common Brain Mapping business.industry Brain Reproducibility of Results Middle Aged Control subjects Image Enhancement Magnetic Resonance Imaging Functional imaging Functional mapping Susceptibility weighted imaging Blood oxygenation Female business Nuclear medicine Artifacts Algorithms |
| Zdroj: | Journal of magnetic resonance imaging : JMRI. 28(5) |
| ISSN: | 1053-1807 |
| Popis: | Purpose: To assess the applicability of T1-weighted images in the presence of a contrast agent for functional mapping free of susceptibility artifacts, in comparison to the blood oxygenation level-dependent (BOLD) imaging. Materials and Methods: Six patients and five control subjects were scanned using BOLD and T1-weighted functional imaging, in the presence of a Gd-DTPA contrastagent (TOFICA). In the control group, low- and highresolution BOLD images were performed. Functional stimuli included motor and language activations. Results: Both BOLD and TOFICA methods resulted in activations in the expected anatomical regions. The TOFICA mapping gave less distributed and with higher percent signal changes in comparison with the BOLD images. GdDTPA remained almost constant in the blood for at least 15 min post injection. In one patient with surgical clips, no signal was detected in the left cerebral hemisphere using BOLD imaging, but activation could be mapped using the TOFICA method. Conclusion: T1-weighted imaging in the presence of a contrast agent can be used for functional mapping. This method is insensitive to susceptibility artifacts, and is therefore advantageous in the evaluation of presurgical cases and in areas of the brain close to cavities in which the BOLD method cannot reliably be applied. |
| Databáze: | OpenAIRE |
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