Investigation of leptomeningeal enhancement in MS: a postcontrast FLAIR MRI study
| Autor: | Kristina Szabo, Britta Engelhardt, Angelika Alonso, Marc E. Wolf, Achim Gass, Martin Griebe, M. G. Hennerici, Philipp Eisele |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis CNS demyelination Contrast Media Fluid-attenuated inversion recovery Blood–brain barrier Cohort Studies Meninges medicine Humans Prospective Studies Prospective cohort study Clinically isolated syndrome medicine.diagnostic_test business.industry Multiple sclerosis Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Blood-Brain Barrier Female Neurology (clinical) Radiology business |
| Zdroj: | Neurology. 84(8) |
| ISSN: | 1526-632X |
| Popis: | Objective: To investigate possible leptomeningeal contrast enhancement using postcontrast fluid-attenuated inversion recovery (FLAIR) MRI as an additional marker of inflammation in patients with multiple sclerosis (MS). Methods: A cohort of 112 patients (73 women) with clinically definitive MS or a clinically isolated syndrome suggestive of CNS demyelination were included. A pathologic control group of 5 stroke patients was also examined. MRI was performed on a 3T system including FLAIR, T2-weighted, T1-weighted–contrast injection, followed by T1-weighted and FLAIR. Results: Of the 112 patients, 39 had an acute relapse at the time of MRI. In total, 96 contrast-enhancing lesions were identified on postcontrast T1-weighted images. The pathologic control group demonstrated the sensitivity of postcontrast FLAIR images demonstrating leptomeningeal enhancement in all cases. In contrast, only 1 out of 112 examined patients with MS showed a single area of abnormal leptomeningeal contrast enhancement. Conclusions: In contrast to intraparenchymal blood–brain barrier (BBB) dysfunction that is frequently seen in patients with MS, BBB dysfunction of leptomeningeal vessels is usually not detectable in patients with early MS. |
| Databáze: | OpenAIRE |
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