| Popis: |
Background : The R o Har antigenic complex has been characterized serologically by difficulties in D typing, weak e expression, lack of G antigen, presence of Rh33, a low-frequency Rh antigen, and, more recently, a second low-frequency antigen, FPTT. Allocation to one of the partial D categories was not considered because of the unusual reactions of R o Har cells and because anti-D production was not observed in R o Har persons. Study Design and Methods : Three unrelated R o Har donors and their families were studied in detail, with special emphasis on D epitope mapping, e and G typing, and screening for antibodies. Results : Only D epitopes 5 and 6/7 were demonstrable, and D epitopes 1, 2, 3, 4, 8, and 9 seem to be absent in the R o Har complex. In one individual, the presence of alloanti-D with limited specificity, not reacting with R o Har red cells of other individuals, was found with months specificity, D+ pregnancy. Conclusion : The finding of alloanti-D in an R o Har r person supports the concept that the D characteristic of this phenotype is a partial D antigen, which is consistent with the presence of the limited number of D epitopes found in epitope mapping. As has been suggested for other partial D antigens, R o Har individuals should be regarded as D- for the receipt of blood, and pregnant R o Har women who have had D+ pregnancies should receive anti-D prophylaxis. |
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