Factors associated with vitrification-warming survival in 6167 euploid blastocysts
| Autor: | Dmitry Gounko, Lucky Sekhon, Margeaux Oliva, Alan B. Copperman, Christine Briton-Jones, Joseph A. Lee |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Pregnancy Rate medicine.medical_treatment Aneuploidy Fertilization in Vitro Cryopreservation Embryo Culture Techniques Andrology Pregnancy Genetics Humans Medicine Genetic Testing Blastocyst Assisted Reproduction Technologies Ovarian reserve Preimplantation Diagnosis Genetics (clinical) Retrospective Studies In vitro fertilisation business.industry Obstetrics and Gynecology Embryo General Medicine Embryo Transfer medicine.disease Antral follicle Vitrification medicine.anatomical_structure Reproductive Medicine embryonic structures Cohort Oocytes Female business Developmental Biology |
| Zdroj: | J Assist Reprod Genet |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/s10815-021-02284-0 |
| Popis: | PURPOSE: To understand the clinical factors associated with embryo survival after vitrification in a cohort of human blastocysts screened by preimplantation genetic testing for aneuploidy (PGT-A). METHODS: Patient demographic, embryo, and cycle characteristics associated with failed euploid blastocyst survival were compared in a cohort of women (n = 6167) who underwent IVF-PGT-A. RESULTS: Compared to those that survived warming, vitrified euploid embryos that failed to survive after warming came from IVF cycles with significantly higher estradiol levels at time of surge (2754.8 ± 1390.2 vs. 2523.1 ± 1190.6 pg/mL, p = 0.03), number of oocytes retrieved (19.6 ± 10.7 vs. 17.5 ± 9.8, p = 0.005), and basal antral follicle count (BAFC) (15.3 ± 8.5 vs. 13.9 ± 7.2, p = 0.05). Euploid embryos were less likely to survive warming if they came from cycles before 2015 (24.6% vs. 13.2%, p |
| Databáze: | OpenAIRE |
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