Biomanufacturing for clinically advanced cell therapies
| Autor: | David Smith, Jay A. Tischfield, Robert Preti, Owen S. Fenton, Ayesha Aijaz, Matthew D. Li, Marcela V. Maus, Daniel G. Anderson, Danika Khong, Jerome Ritz, Biju Parekkadan, Robert Deans, Courtney LeBlon, Rita N. Barcia, Ronke M. Olabisi, Steven Libutti |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Chemical Engineering, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Harvard University--MIT Division of Health Sciences and Technology, Koch Institute for Integrative Cancer Research at MIT |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Extramural medicine.medical_treatment Cell Cell- and Tissue-Based Therapy Biomedical Engineering Medicine (miscellaneous) Bioengineering Immunotherapy Article Chimeric antigen receptor Computer Science Applications 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure medicine Humans Biomanufacturing Stem cell Intensive care medicine business Biotechnology |
| Zdroj: | BASE-Bielefeld Academic Search Engine PMC |
| Popis: | The achievements of cell-based therapeutics have galvanized efforts to bring cell therapies to the market. To address the demands of the clinical and eventual commercial-scale production of cells, and with the increasing generation of large clinical datasets from chimeric antigen receptor T-cell immunotherapy, from transplants of engineered haematopoietic stem cells and from other promising cell therapies, an emphasis on biomanufacturing requirements becomes necessary. Robust infrastructure should address current limitations in cell harvesting, expansion, manipulation, purification, preservation and formulation, ultimately leading to successful therapy administration to patients at an acceptable cost. In this Review, we highlight case examples of cutting-edge bioprocessing technologies that improve biomanufacturing efficiency for cell therapies approaching clinical use. |
| Databáze: | OpenAIRE |
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