Persistence of right ventricular dysfunction and altered morphometry in asymptomatic preterm Infants through one year of age: Cardiac phenotype of prematurity
| Autor: | Aaron Hamvas, Collin T. Erickson, Ling Li, Gautam K. Singh, Tim Sekarski, Philip T. Levy, Meghna D. Patel, Mary Craft, Afif El Khuffash, Swati Choudhry, Karl Stessy M. Bisselou, Shelby Kutty |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Hypertension Pulmonary Ventricular Dysfunction Right Infant Premature Diseases 030204 cardiovascular system & hematology Asymptomatic Article Persistence (computer science) 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine medicine Humans Bronchopulmonary Dysplasia Retrospective Studies Ventricular Remodeling business.industry Infant Newborn Infant General Medicine medicine.disease Pulmonary hypertension Right ventricular dysfunction medicine.anatomical_structure Bronchopulmonary dysplasia Ventricle Echocardiography Pediatrics Perinatology and Child Health Cohort Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Cardiac phenotype Infant Premature |
| Zdroj: | Cardiology in the young. 29(7) |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | Introduction:Prematurity impacts myocardial development and may determine long-term outcomes. The objective of this study was to test the hypothesis that preterm neonates develop right ventricle dysfunction and adaptive remodelling by 32 weeks post-menstrual age that persists through 1 year corrected age.Materials and Methods:A subset of 80 preterm infants (born Result:In both term and preterm infants, right ventricle function and morphology increased over the first year (p < 0.01). The magnitudes of right ventricle function measures were lower in preterm-born infants at each time period (p < 0.01 for all) and right ventricle morphology indices were wider in all preterm infants by 1 year corrected age, irrespective of lung disease. Measures of a) right ventricle function were further decreased and b) morphology increased through 1 year in preterm infants with bronchopulmonary dysplasia and/or pulmonary hypertension (p < 0.01).Conclusion:Preterm infants exhibit abnormal right ventricle performance with remodelling at 32 weeks post-menstrual age that persists through 1 year corrected age, suggesting a less developed intrinsic myocardial function response following preterm birth. The development of bronchopulmonary dysplasia and pulmonary hypertension leave a further negative impact on right ventricle mechanics over the first year of age. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|