CSF interleukin 6 is a useful marker to distinguish pseudotumoral CNS inflammatory diseases from primary CNS lymphoma
| Autor: | Timothée Parratte, Myrto Costopoulos, Guido Ahle, I Alamome, Magali Le Garff-Tavernier, Remy Hurstel, A Brinet, Claude Gaultier, Hélène Durand, Aurelian Ungureanu, François Sellal |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pathology Neurology Lymphoma Granuloma Plasma Cell Central Nervous System Neoplasms Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Interquartile range hemic and lymphatic diseases Biomarkers Tumor medicine Humans 030212 general & internal medicine Interleukin 6 Retrospective Studies biology Interleukin-6 business.industry Primary central nervous system lymphoma medicine.disease Interleukin 10 biology.protein Biomarker (medicine) Neurology (clinical) Differential diagnosis business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology. 268:2890-2894 |
| ISSN: | 1432-1459 0340-5354 |
| Popis: | Interleukin 6 (IL-6) is a pleomorphic cytokine that can be found in the cerebrospinal fluid (CSF) in a wide spectrum of inflammatory pathologies of the central nervous system (CNS). Our aim was to characterize the diagnostic significance of CSF IL-6 among various CNS inflammatory diseases with pseudotumoral lesions (CNSID) and primary CNS lymphoma (PCNSL). We retrospectively analyzed the CSF IL-6 concentrations in 43 consecutive patients with suspected PCNSL. A total of 28 patients were positively diagnosed with PCNSL and 15 with CNSID. We verified the results with CSF IL-10, an established biomarker for PCNSL. In the PCNSL group, the median CSF IL-6 concentration was 8 pg/ml, interquartile range (IQR) 5–18.5. For the patients with CNSID, the median concentration was 70 pg/ml, IQR 5–1368. A group comparison showed significantly higher CSF IL-6 levels in patients with CNSID than in those with PCNSL (p = 0.032). Moreover, IL-6 was correlated with CSF cell count in the CNSID group (r = 0.56, p = 0.028), but not in the PCNSL group (r = 0.3, p = 0.13). We found significantly higher CSF IL-10 levels in patients with PCNSL than in patients with CNS inflammatory lesions (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink