Specific mutation in exon 11 of c- kit proto-oncogene in a malignant gastrointestinal stromal tumor of the rectum
| Autor: | Tadashi Matsumoto, Yutaka Endo, Masahiko Yamaguchi, Akihiko Matsumiya, Michiko Miyaki, Kaoru Kumada, Yutaka Sanada, M Kuzume, Takeshi Iijima |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Oncogene GiST Rectal Neoplasms Abdominoperineal resection Liver Neoplasms Gastroenterology CD34 Rectum Exons Middle Aged Biology Proto-Oncogene Mas Malignant Gastrointestinal Stromal Tumor Proto-Oncogene Proteins c-kit Exon medicine.anatomical_structure Mutation Proto-Oncogenes medicine Cancer research Humans Stromal tumor |
| Zdroj: | Journal of Gastroenterology. 35:779-783 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/s005350070038 |
| Popis: | Gastrointestinal stromal tumor (GIST) in the distal third of the rectum was detected in a 57-year-old man who underwent an abdominoperineal resection of the rectum. Because the tumor expressed CD34 and c-kit gene product, but did not express smooth muscle actin or S-100 protein, it was diagnosed as an uncommitted type of GIST. Moreover, a specific mutation in the sequence coding the juxtamembrane domain in exon 11 of the c-kit proto-oncogene was revealed by a polymerase chain reaction-single-strand conformation polymorphism method. One year after resection, the patient developed multiple liver metastases. It is suggested that a specific mutation in exon 11 of the c-kit proto-oncogene may have played an essential role in the development of the liver metastases. |
| Databáze: | OpenAIRE |
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