Bacterial Metabolites of Human Gut Microbiota Correlating with Depression

Autor: Yana Zorkina, Alexey S. Kovtun, George P. Kostyuk, Valery N. Danilenko, Olga V. Averina, Vladimir P. Chekhonin, V. M. Ushakova, Roman A. Yunes, Anna Morozova
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Gut–brain axis
Review
Gut flora
aminoacids
Bioinformatics
Catalysis
neurotransmitters
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
Human gut
Functional Food
Humans
Medicine
Amino Acids
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
functional foods
Spectroscopy
Depression (differential diagnoses)
psychobiotics
Neurotransmitter Agents
Bacteria
biology
gut microbiota
business.industry
gut-brain axis
Organic Chemistry
Brain
biomarkers
General Medicine
biology.organism_classification
Mental health
Gastrointestinal Microbiome
Computer Science Applications
Clinical Practice
Clinical therapy
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
depression
Disease Susceptibility
Energy Metabolism
business
030217 neurology & neurosurgery
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 9234, p 9234 (2020)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: Depression is a global threat to mental health that affects around 264 million people worldwide. Despite the considerable evolution in our understanding of the pathophysiology of depression, no reliable biomarkers that have contributed to objective diagnoses and clinical therapy currently exist. The discovery of the microbiota-gut-brain axis induced scientists to study the role of gut microbiota (GM) in the pathogenesis of depression. Over the last decade, many of studies were conducted in this field. The productions of metabolites and compounds with neuroactive and immunomodulatory properties among mechanisms such as the mediating effects of the GM on the brain, have been identified. This comprehensive review was focused on low molecular weight compounds implicated in depression as potential products of the GM. The other possible mechanisms of GM involvement in depression were presented, as well as changes in the composition of the microbiota of patients with depression. In conclusion, the therapeutic potential of functional foods and psychobiotics in relieving depression were considered. The described biomarkers associated with GM could potentially enhance the diagnostic criteria for depressive disorders in clinical practice and represent a potential future diagnostic tool based on metagenomic technologies for assessing the development of depressive disorders.
Databáze: OpenAIRE
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