Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones
| Autor: | Min Kim, Jen-Chieh Hsieh, Hasil Aman, Yu-Hao Liu, Gary Jing Chuang, Yu-Chiao Huang, Yu-Lin Tsai |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Reaction mechanism
cyclization N-heterocycle cobalt-catalyzed Pharmaceutical Science chemistry.chemical_element Organic chemistry Article Analytical Chemistry Catalysis chemistry.chemical_compound QD241-441 Drug Discovery Physical and Theoretical Chemistry Carbodiimide Nucleophilic addition carbodiimide Substitution (logic) 3-(imino)isoindolin-1-one Combinatorial chemistry chemistry Chemistry (miscellaneous) Molecular Medicine Cobalt |
| Zdroj: | Molecules, Vol 26, Iss 7212, p 7212 (2021) Molecules Molecules; Volume 26; Issue 23; Pages: 7212 |
| ISSN: | 1420-3049 |
| Popis: | A novel synthetic pathway to approach 3-(imino)isoindolin-1-ones by the Co-catalyzed cyclization reaction of 2-bromobenzamides with carbodiimides has been developed. This catalytic reaction can tolerate a variety of substituents and provide corresponding products in moderate yields for most cases. According to the literature, the reaction mechanism is proposed through the formation of a five-membered aza-cobalacycle complex, which carries out the following reaction subsequence, including nucleophilic addition and substitution, to furnish the desired structures. |
| Databáze: | OpenAIRE |
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