Loss of Plasmacytoid Dendritic Cell Function Coincides with Lymphopenia and Viremia During Foot-and-Mouth Disease Virus Infection
| Autor: | Juan M. Pacheco, Mary Kenney, William T. Golde, Felix N. Toka, Charles K. Nfon |
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| Rok vydání: | 2010 |
| Předmět: |
Serotype
Swine animal diseases viruses Immunology Viremia Plasmacytoid dendritic cell Virus Immune tolerance Immune system Lymphopenia Virology Immune Tolerance medicine Animals Swine Diseases Foot-and-mouth disease biology Interferon-alpha virus diseases Dendritic Cells biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Foot-and-Mouth Disease Virus Foot-and-Mouth Disease Molecular Medicine Foot-and-mouth disease virus |
| Zdroj: | Viral Immunology. 23:29-41 |
| ISSN: | 1557-8976 0882-8245 |
| DOI: | 10.1089/vim.2009.0078 |
| Popis: | Foot-and-mouth disease virus (FMDV) causes an acute, highly contagious disease of livestock. Though FMDV is very sensitive to interferon-alpha (IFN-alpha), IFN-beta, and IFN-gamma, the virus has evolved mechanisms to evade such innate responses. For instance, during acute infection, FMDV suppresses IFN-alpha production by skin and myeloid dendritic cells (DCs). We have previously reported that FMDV infection induces a transient lymphopenia and interruption of T-lymphocyte responses to mitogenic stimuli. To further understand the immunopathogenesis of FMD, we have now analyzed the serum IFN-alpha response in relation to lymphopenia, and the number and function of plasmacytoid DCs (pDCs) following infection of pigs with multiple serotypes of FMDV. Serum IFN-alpha peaked 2-3 d post-infection (PI), regardless of FMDV serotype. Lymphopenia coincided with peak viremia and the serum IFN-alpha response. Circulating pDC numbers and in-vitro pDC IFN-alpha secretion transiently declined by 48 h following infection. Infection of lymphocytes or pDCs was never detected regardless of the FMDV serotype inoculated or the age of the animal infected. These data indicate that, like other DC subsets, there is suppression of interferon production by pDCs, which abrogates this important innate response. Rapid induction of serum IFN-alpha, albeit short-lived, may contribute to the rapid resolution of FMDV viremia prior to induction of specific immunity. |
| Databáze: | OpenAIRE |
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