Nanocrystals as an effective strategy to improve Pomalidomide bioavailability in rodent

Autor: Maria Cristina Cardia, Maria Francesca Palmas, Luca Casula, Augusta Pisanu, Salvatore Marceddu, Donatella Valenti, Chiara Sinico, Elena Pini, Michael T. Scerba, David Tweedie, Nigel H. Greig, Anna Rosa Carta, Francesco Lai
Rok vydání: 2022
Předmět:
Zdroj: International journal of pharmaceutics. 625
ISSN: 1873-3476
Popis: Pomalidomide (POM) is an FDA-approved immunomodulatory imide drug (IMiDs) an it is effectively used in the treatment of multiple myeloma. IMiDs are analogs of the drug thalidomide and they have been repurposed for the treatment of several diseases such as psoriatic arthritis and Kaposi Sarcoma. In recent years, IMiDs have been also evaluated as a new treatment for neurological disorders with an inflammatory and neuroinflammatory component. POM draws particular interest for its potent anti-TNF-α activity at significantly lower concentrations than the parent compound thalidomide. However, POM's low water solubility underpins its low gastrointestinal permeability resulting in irregular and poor absorption. The purpose of this work was to prepare a POM nanocrystal-based formulation that could efficiently improve POM's plasma and brain concentration after intraperitoneal injection. POM nanocrystals prepared as a nanosuspension by the media milling method showed a mean diameter of 219 nm and a polydispersity index of 0.21. POM's nanocrystal solubility value (22.97 µg/mL) in phosphate buffer was about 1.58 folds higher than the POM raw powder. Finally, in vivo studies conducted in adult Male Sprague-Dawley rats indicated that POM nanocrystal ensured higher and longer-lasting drug levels in plasma and brain when compared with POM coarse suspension.
Databáze: OpenAIRE
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