Frequency, Clinical Characteristics and Outcome of Adults With Acute Lymphoblastic Leukemia and COVID 19 Infection in the First vs. Second Pandemic Wave in Spain

Autor: María-Teresa Artola, Teresa Giménez-Pérez, Cristina Gil, Marisa Calabuig, Pere Barba, José-Luis Piñana, María-Dolores Morales, Juan Bergua, María-Carmen Mateos, Laura Llorente, Ainhoa Fernández-Moreno, Pau Montesinos, Josep-Maria Ribera, Clara Maluquer, Rosa Coll, Anna Torrent, María-José Sánchez-Sánchez, Guiomar Bautista, Abelardo Bárez, José González-Campos, Jose-Luis Lopez-Lorenzo, Irene García-Cadenas, María-Rosario Varela, Monica Cabrero, Pilar Herrera, Maria Angeles Foncillas, Ignacio Gómez-Centurión, Mireia Morgades, Antoni Garcia-Guiñon, María Calbacho
Rok vydání: 2021
Předmět:
Zdroj: Clinical lymphoma, myeloma & leukemia
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Clinical Lymphoma, Myeloma & Leukemia
Clinical Lymphoma Myeloma & Leukemia
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
ISSN: 2152-2650
Popis: Background and objective SARS-CoV-2 infection has bimodal distribution in Europe with a first wave in March to June 2020 and a second in September 2020 to February 2021. We compared the frequency, clinical characteristics and outcomes of adults with acute lymphoblastic leukemia (ALL) and infection in the first vs. second pandemic waves in Spain. Patients and Methods In this prospective study the characteristics of ALL and COVID-19 infection, comorbidities, treatment and outcome in the two periods were compared. The study ended when vaccination against SARS-CoV-2 was implemented in Spain. Results Twenty eight patients were collected in the first wave and 24 in the second. The median age was 46.5 years (range 20–83). Patients from the first wave had a trend to more severe ALL (higher frequency of patients under induction or submitted to transplantation or under immunosuppressive therapy). No significant differences were observed in need for oxygen support, intensive care unit (ICU) requirement, days in ICU and time to COVID-19 infection recovery. Seventeen patients (33%) died, with death attributed to COVID infection in 15 (29%), without significant differences in the 100 day overall survival (OS) probabilities in the two waves (68% ± 17% vs. 56% ± 30%). The only prognostic factor for OS identified by was the presence of comorbidities at COVID-19 infection (HR: 5.358 [95% CI: 1.875- 15.313]). Conclusion The frequency and mortality of COVID-19 infection were high in adults with ALL, without changes over time, providing evidence in favor of vaccination priority for these patients.
Microabstract The characteristics and outcome of ALL in adults with COVID-19 infection in the first two waves of the pandemic in Spain were compared. The frequency and mortality of COVID-19 infection were high in adults with ALL, without changes over time. Comorbidities at COVID-19 infection was the only prognostic factor for survival.
Databáze: OpenAIRE
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