IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity
| Autor: | Julia H.B. Steiner, Jean Philippe Theurillat, Bernhard C. Pestalozzi, Zsuzsanna Varga, Dimitri Korol, Holger Moch, Ursina Zürrer-Härdi, Nicole Probst-Hensch, Daniel Fink, Martina Storz, Urs M. Lütolf, Peter Schraml, Mathias K. Fehr |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty IGFBP3 Breast Neoplasms Breast cancer Internal medicine medicine Humans Obesity Insulin-Like Growth Factor I Estrogen Receptor Status Progesterone Aged Tissue microarray business.industry Cancer Middle Aged medicine.disease Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor Binding Protein 2 Endocrinology Insulin-Like Growth Factor Binding Protein 3 Receptors Estrogen Hormone receptor Female Breast disease business Body mass index |
| Zdroj: | Clinical cancer research : an official journal of the American Association for Cancer Research. 16(3) |
| ISSN: | 1557-3265 |
| Popis: | Purpose: The insulin-like growth factor (IGF) signaling system is involved in breast cancer initiation and progression. The prognostic relevance of tumor expression patterns of IGFI-related proteins remains poorly understood. This study associates the expression of selected IGF proteins with breast tumor and patient characteristics. Experimental Design: IGFI, IGFI receptor, IGF-binding protein (IGFBP)2, and IGFBP3 expression was measured in 855 primary breast carcinomas by immunohistochemistry using tissue microarrays. We investigated the association of tumor and nodal stage, grade, hormone receptor status, HER2 gene amplification, menopausal status, body mass index, and survival with IGF protein expression. Results: In contrast to IGFI, the expression of IGFI receptor, IGFBP2, and IGFBP3 was associated with estrogen receptor status. In addition, IGFBP3 was positively correlated with body mass index and premenopausal status. Importantly, IGFBP2 was an independent and positive predictor of overall survival (hazard ratio, 0.48; 95% confidence interval, 0.24-0.95; P = 0.04). There was a weak suggestion for IGFBP2 and overweight to modify each other's effect on survival. Conclusions: According to these results, which need confirmation in larger patient series, the prognostic relevance of IGFBP2 and IGFBP3 protein expressions in breast cancer may depend on the hormonal context and body weight. Clin Cancer Res; 16(3); 1025–32 |
| Databáze: | OpenAIRE |
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