Epidemiology and Treatment Outcomes of Sinonasal Tumors: A Single Institute's Experience in Pakistan
| Autor: | Rab Nawaz Maken, Hasan Nisar, Wajiha Anjum, Ismat Fatima, Misbah Masood, Abu Baker Shahid |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment 030204 cardiovascular system & hematology Gastroenterology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology medicine Carcinoma Humans Pakistan Stage (cooking) Survival rate Aged business.industry Chemoradiotherapy Adjuvant General Medicine Middle Aged medicine.disease Otorhinolaryngologic Surgical Procedures Survival Rate Radiation therapy Log-rank test Treatment Outcome Paranasal sinuses medicine.anatomical_structure Chemotherapy Adjuvant Carcinoma Squamous Cell Female Nasal Cavity business Paranasal Sinus Neoplasms 030217 neurology & neurosurgery Chemoradiotherapy |
| Zdroj: | Journal of the College of Physicians and Surgeons Pakistan. 29:356-360 |
| ISSN: | 1681-7168 1022-386X |
| DOI: | 10.29271/jcpsp.2019.04.356 |
| Popis: | OBJECTIVE To find the epidemiology and risk factors of sinonasal tumors and treatment outcomes in squamous cell carcinoma. STUDY DESIGN An observational study. PLACE AND DURATION OF STUDY The Institute of Nuclear Medicine and Oncology Lahore (INMOL), Lahore, from May 2016 to March 2017. METHODOLOGY All histopathologically proven cases of paranasal sinuses and nasal cavity were selected from the hospital record for epidemiological analysis. Survival outcomes of patients with squamous cell histopathology were determined, which is commonly occurring type. Relevant information was obtained from patient record and telephone communication. The data were analysed using SPSS V.20. RESULTS Sinonasal malignancies are rare, making (n=81) 0.2% of all registered tumors; out of which, 46 (56.7%) had squamous cell histology. Median age was 50.0 years (IQR: 60.7-40.0) with male predominance (1.7:1). Most of patients presented at advanced stage, T3/ T4 in more than two-thirds of cases, and associated with nodal metastasis in 43.5% of squamous cell carcinoma. In patients with squamous cell histology, median disease-free survival was 19.00 months (SE: 1.65, 95% CI, 15.75 - 22.25), median overall survival remained 34.00 months (SE: 1.84, 95% CI, 30.00 - 38.00). Nodal status had significant effect (p |
| Databáze: | OpenAIRE |
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