Placental expression of angiogenic factors in Trisomy 13
| Autor: | Isaac E. Stillman, S. Ananth Karumanchi, Camille E. Powe, Michelle Silasi, Bruce M. Cohen, Sarosh Rana, Kee-Hak Lim, Zsuzsanna K. Zsengellér |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Trisomy 13 Syndrome Placenta H&E stain Chromosome Disorders Trisomy Preeclampsia Andrology Young Adult Pregnancy medicine Humans Statistical analysis Retrospective Studies Gynecology Vascular Endothelial Growth Factor Receptor-1 biology Chromosomes Human Pair 13 business.industry Placental expression Obstetrics and Gynecology Middle Aged medicine.disease Staining medicine.anatomical_structure Case-Control Studies embryonic structures biology.protein Female Antibody business |
| Zdroj: | American journal of obstetrics and gynecology. 204(6) |
| ISSN: | 1097-6868 |
| Popis: | Objective Increased levels of soluble fms-like tyrosine kinase (sFlt-1) in Trisomy 13 pregnancies are thought to be mediated by the placenta. This study aimed to compare sFlt-1 expression in Trisomy 13 (n = 7) placentas with that in control placentas (Trisomy 21, n=11, and euploid, n=6). Study Design This was a retrospective case-control study analyzing paraffin-embedded placental blocks that were stained with hematoxylin and eosin and antibodies to sFlt-1. Their staining intensity was compared using a semiquantitative technique. The Kruskal-Wallis test and Wilcox rank sum test were used for statistical analysis. Results The median staining was significantly higher in Trisomy 13 compared with control specimens ( P = .008) (for Trisomy 13 vs Trisomy 21, P = .003, and Trisomy 13 vs euploid, P = .004). Conclusion Our study demonstrates that Trisomy 13 placentas express more sFlt-1 than control placentas. These results strengthen the hypothesis that the increased incidence of preeclampsia in Trisomy 13 pregnancies is secondary to placental up-regulation of sFlt-1. |
| Databáze: | OpenAIRE |
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