Computational analysis of a microRNA signature for poor prognosis suggests a microRNA ‐controlled stemness pathway in paediatric acute leukaemia

Autor: Stefan J. Erkeland
Přispěvatelé: Immunology
Rok vydání: 2023
Předmět:
Zdroj: British Journal of Haematology. Wiley-Blackwell Publishing Ltd
ISSN: 1365-2141
0007-1048
Popis: Esperanza-Cebollada E., et al. found a group of 24 microRNAs, to be differentially expressed between two groups of paediatric acute myeloid leukaemia (AML) cases with distinct outcomes. The main target of this microRNA signature is SOCS2, a gene that controls stemness. The results of this study may open doors for further investigation of the role for microRNAs in poor prognostic paediatric AML. Commentary on: Esperanza-Cebollada et al. A miRNA signature related to stemness identifies high-risk patients in paediatric acute myeloid leukaemia. Br J Haematol 2023 (Online ahead of print). doi: 10.1111/bjh.18746.
Databáze: OpenAIRE
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