The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation

Autor: Katsutoshi Miyosawa, Haruna Tabuchi, Asuka Minami-Takano, Masataka Sumiyoshi, Kai Ishii, Tomoyuki Shiozawa, Takehiro Funamizu, Hiroshi Iwata, Hiroyuki Daida, Kazunori Shimada, Gaku Sekita, Yuji Nakazato, Hidemori Hayashi, Tohru Minamino, Yui Nozaki
Rok vydání: 2021
Předmět:
Male
medicine.medical_treatment
030204 cardiovascular system & hematology
chemistry.chemical_compound
0302 clinical medicine
Atrial Fibrillation
Cyclic AMP
Medicine
030212 general & internal medicine
Multidisciplinary
biology
Atrial fibrillation
Middle Aged
Pathophysiology
Cholesterol
cardiovascular system
Cardiology
Female
lipids (amino acids
peptides
and proteins)
Cardiac regeneration
Lipoproteins
HDL
ATP Binding Cassette Transporter 1
medicine.medical_specialty
Science
Catheter ablation
Article
03 medical and health sciences
Internal medicine
Humans
cardiovascular diseases
Heart Atria
Aged
business.industry
Cholesterol
HDL
nutritional and metabolic diseases
Atrial Remodeling
Odds ratio
medicine.disease
Cardiovascular biology
Confidence interval
Cross-Sectional Studies
chemistry
ABCA1
biology.protein
business
Lipoprotein
Zdroj: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
ISSN: 2045-2322
DOI: 10.1038/s41598-021-82998-4
Popis: This cross-sectional study enrolled 202 patients with atrial fibrillation (AF) who had undergone catheter ablation and evaluated the association between high-density lipoprotein (HDL) functionality, cholesterol efflux capacity (CEC) of HDL, and the pathophysiology of left atrial structural remodeling. Participants were divided into two groups, based on their left atrial volume index (LAVI) (2, n = 60 vs. LAVI ≥ 34 mL/m2, n = 142). We quantified three types of HDL CECs by the presence or absence of cyclic-AMP, as entire, and CEC dependent or not dependent on ATP binding cassette transporter A1 (ABCA1) and termed them Global CEC, ABCA1 CEC, and Non-ABCA1 CEC, respectively. Consequently, Global and Non-ABCA1 CECs were significantly impaired in patients with an enlarged LA (Global CEC: p = 0.039, Non-ABCA1 CEC: p = 0.022). Logistic regression analyses demonstrated that Non-ABCA1 CEC was significantly associated with an enlarged LA after adjusting for the conventional risk factors of AF. Furthermore, the association of higher Non-ABCA1 CEC with an enlarged LA was independent of serum levels of HDL cholesterol and serum myeloperoxidase (Odds ratio of 1 standard deviation higher: 0.64, 95% confidence interval: 0.43–0.95, p = 0.027). The findings of this study indicate the potential contribution of reduced Non-ABCA1 CEC in HDL to the pathophysiology in left atrial structural remodeling of patients with AF.
Databáze: OpenAIRE
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