C-terminal nucleophosmin mutations are uncommon in chronic myeloid disorders
| Autor: | Chin Yang Li, Alexander Sternberg, Ayalew Tefferi, Terra L. Lasho, David P. Steensma, Jonathan S. Caudill |
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| Rok vydání: | 2006 |
| Předmět: |
NPM1
medicine.medical_specialty Myeloid DNA Mutational Analysis Molecular Sequence Data Biology medicine.disease_cause Germline mutation hemic and lymphatic diseases Internal medicine Gene duplication medicine Humans Bone Marrow Diseases Nucleophosmin Mutation Myeloproliferative Disorders Hematology Base Sequence integumentary system Nuclear Proteins Leukemia Myelomonocytic Chronic DNA Neoplasm Prognosis medicine.disease Leukemia Cell Transformation Neoplastic medicine.anatomical_structure Myelodysplastic Syndromes Chronic Disease Immunology Disease Progression |
| Zdroj: | British Journal of Haematology. 133:638-641 |
| ISSN: | 1365-2141 0007-1048 |
| Popis: | C-terminal somatic mutations in nucleophosmin (NPM), a nucleolar shuttling protein that binds p53 and p19(Arf), were recently described in karyotypically normal acute myeloid leukaemia (AML). We analysed primary marrow samples from 150 patients with various chronic myeloid disorders for mutations in the NPM1 gene encoding NPM. NPM1 mutations (tetranucleotide duplication) were detected in three patients, all of whom had chronic myelomonocytic leukaemia (CMML) and a short ( |
| Databáze: | OpenAIRE |
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