Molecular chaperones, α-synuclein, and neurodegeneration
| Autor: | Stephan N. Witt |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cell signaling
Programmed cell death Parkinson's disease Cytoplasmic inclusion animal diseases Neuroscience (miscellaneous) Cell Communication Biology Article Cellular and Molecular Neuroscience chemistry.chemical_compound medicine Animals Humans heterocyclic compounds Alpha-synuclein Neurotransmitter Agents Cell Death Neurodegeneration Dopaminergic Neurodegenerative Diseases medicine.disease Cell biology nervous system diseases Neurology chemistry nervous system alpha-Synuclein Neuroscience Molecular Chaperones |
| Zdroj: | Molecular neurobiology. 47(2) |
| ISSN: | 1559-1182 |
| Popis: | Parkinson’s disease (PD) is a devastating neurological condition that affects about 1 % of people older than 65 years of age. In PD, dopaminergic neurons in the mid-brain slowly accumulate cytoplasmic inclusions (Lewy bodies, LBs) of the protein alpha-synuclein (α-syn) and then gradually lose function and die off. Cell death is thought to be causally linked to the aggregation/fibrillization of α-syn. This review focuses on new findings about the structure of α-syn, about how α-syn cooperates with Hsp70 and Hsp40 chaperones to promote neurotransmitter release, and about cell-to-cell transfer of pathogenic forms of α-syn and how Hsp70 might protect against this disease process. |
| Databáze: | OpenAIRE |
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