Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors
| Autor: | Nor Azman N. I. Iwana, Rashad Al-Salahi, Mohamed Marzouk, El Hassane Anouar, Hatem A. Abuelizz, Rohaya Ahmad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pyrido-triazolopyrimidine
Stereochemistry 010402 general chemistry 01 natural sciences lcsh:Chemistry Hydrolysis medicine Binding site IC50 Acarbose chemistry.chemical_classification 010405 organic chemistry Biological activity General Chemistry 0104 chemical sciences Enzyme Postprandial chemistry α-Glucosidase Antidiabetic lcsh:QD1-999 Molecular docking Tricyclic medicine.drug Research Article |
| Zdroj: | BMC Chemistry, Vol 13, Iss 1, Pp 1-14 (2019) BMC Chemistry |
| DOI: | 10.1186/s13065-019-0560-4 |
| Popis: | Diabetes is an emerging metabolic disorder. α-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes. This action decreases the glucose absorption and the postprandial glucose level. We have synthesized 25 tricyclic 2-phenoxypyrido[3,2-e][1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones hybrids and evaluated their α-glucosidase inhibitory activity. Compounds 6h and 6d have shown stronger activity than that of acarbose. Compound 6h exhibited the highest inhibition with an IC50 of 104.07 µM. Molecular modelling studies revealed that compound 6h inhibits α-glucosidase due to the formation of a stable ligand-α-glucosidase complex and extra hydrogen bond interactions, and directed in the binding site by Trp329.25 tricyclic 2-phenoxypyrido[3,2-e][1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones hybrids have been synthesized and evaluated their α-glucosidase inhibitory activity. Compounds 6h have shown stronger activity than that of acarbose |
| Databáze: | OpenAIRE |
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