Post-pubertal emergence of alterations in locomotor activity in stop null mice

Autor: Annie Andrieux, Jean-Baptiste Bertrand, Thierry d'Amato, Didier Job, Marie-Françoise Suaud-Chagny, Mélina Bégou, Philippe Brun, Annie Schweitzer, Mohamed Saoud
Přispěvatelé: Psychopathologie et neurobiologie de la schizophrénie et de la vulnérabilité à la psychose, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-IFR19-Centre Hospitalier le Vinatier [Bron], Groupe Physiopathologie du Cytosquelette (GPC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Andrieux, Annie, Centre Hospitalier le Vinatier [Bron]-IFR19-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Male
Aging
[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
MESH: Mice
Knockout
MESH: Dose-Response Relationship
Drug
Mice
Basal (phylogenetics)
0302 clinical medicine
MESH: Behavior
Animal
MESH: Aging
MESH: Animals
Mice
Knockout
0303 health sciences
MK-801
Behavior
Animal
Dopaminergic
MESH: Excitatory Amino Acid Antagonists
prodrome
MESH: Motor Activity
Schizophrenia
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
MESH: Exploratory Behavior
Psychology
Microtubule-Associated Proteins
medicine.drug
medicine.medical_specialty
Period (gene)
amphetamine
Motor Activity
MESH: Central Nervous System Stimulants
Prodrome
microtubules
03 medical and health sciences
Cellular and Molecular Neuroscience
Glutamatergic
Internal medicine
MESH: Analysis of Variance
MESH: Amphetamine
medicine
Animals
Juvenile
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Amphetamine
MESH: Mice
030304 developmental biology
Analysis of Variance
Dose-Response Relationship
Drug
MESH: Dizocilpine Maleate
medicine.disease
MESH: Male
schizophrenia
MESH: Microtubule-Associated Proteins
Endocrinology
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Exploratory Behavior
Central Nervous System Stimulants
Dizocilpine Maleate
Excitatory Amino Acid Antagonists
Neuroscience
030217 neurology & neurosurgery
Zdroj: Synapse
Synapse, Wiley-Blackwell, 2007, 61 (9), pp.689-97. ⟨10.1002/syn.20409⟩
Synapse, 2007, 61 (9), pp.689-97. ⟨10.1002/syn.20409⟩
Synapse / Synapse (Hoboken)
Synapse / Synapse (Hoboken), 2007, 61 (9), pp.689-97. ⟨10.1002/syn.20409⟩
ISSN: 0887-4476
1098-2396
DOI: 10.1002/syn.20409⟩
Popis: International audience; Overt schizophrenia is preceded by a prodromal phase during which juvenile patients display attenuated schizophrenia-related symptoms. Here, we have looked for evidence of a prodromal phase in juvenile STOP null mice, which, during adulthood, imitate features of schizophrenia. We have principally examined locomotor activity, which is abnormal in adult STOP null mice, and its apparent relationship with perturbed glutamatergic and dopaminergic transmission. When compared to corresponding wild-type mice, juvenile STOP null mice did not exhibit the basal hyperlocomotion or locomotor hypersensitivity to mild stress observed in adult mice. Juvenile STOP null mice also lacked disturbed locomotor sensitivity to MK-801, which was evident in adult mice. In contrast, juvenile STOP null mice exhibited a similar hypersensitivity to amphetamine as that found in adult mice. Thus, STOP null mice exhibited both a progression of locomotor activity defects over time and subtle alterations in the prepubertal period. We suggest that the pattern of locomotor disturbances observed in this study is related to altered dopaminergic reactivity in juvenile mice without major disturbance in glutamatergic transmission, whereas both neurotransmitter systems are impaired in adult mice.
Databáze: OpenAIRE
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