Verapamil and Myocardial Preservation in Patients Undergoing Coronary Artery Bypass Surgery
| Autor: | Anita V. Guffin, Robert A. Kates, Joel A. Kaplan, G. Wayne Holbrook, Ellis L. Jones |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine Inotrope Cardiac function curve medicine.medical_specialty Ischemia law.invention Coronary artery bypass surgery Verapamil Hydrochloride law Internal medicine medicine Cardiopulmonary bypass Humans Coronary Artery Bypass Aged business.industry Heart Middle Aged Hypothermia medicine.disease Verapamil Anesthesia Heart Arrest Induced cardiovascular system Cardiology Surgery medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The Annals of Thoracic Surgery. 41:587-591 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/s0003-4975(10)63065-2 |
| Popis: | The value of verapamil hydrochloride as a myocardial preservative when administered prior to or during periods of myocardial ischemia was studied in patients with normal preoperative cardiac function during elective coronary artery bypass grafting. Myocardial protection included systemic hypothermia (28°C) and hypothermic hyperkalemic cardioplegia. Patients were randomly divided into four groups. Group 1 received intravenous administration of verapamil prior to aortic cross-clamping. Group 2 received intravenous verapamil plus verapamil in the cardioplegic solution. Group 3 received verapamil in the cardioplegic solution only. Group 4 was given no verapamil. Oxygen extraction during the reperfusion period was greatest in Group 4. However, the incidence of pacing was 50 to 78% in Groups 2 and 3, who were given verapamil in the cardioplegic solution. These groups also had a greater need for inotropic agents for discontinuation of cardiopulmonary bypass (CPB). This study indicates that verapamil may be a useful pretreatment prior to CPB and ischemia, but is not effective and may even be detrimental when administered during ischemic periods to patients with good myocardial function. |
| Databáze: | OpenAIRE |
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