Intense exercise increases circulating endocannabinoid and BDNF levels in humans—Possible implications for reward and depression
| Autor: | Fabiana Piscitelli, Bart Roelands, V. Di Marzo, Elsa Heyman, Erwan Leclair, Maaike Goekint, François-Xavier Gamelin, Romain Meeusen |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Polyunsaturated Alkamides Endocrinology Diabetes and Metabolism Oleic Acids Arachidonic Acids Palmitic Acids Mass Spectrometry Glycerides Young Adult chemistry.chemical_compound Endocrinology Reward Neurotrophic factors Internal medicine Cannabinoid Receptor Modulators medicine Humans PPAR alpha Exercise physiology Exercise Chromatography High Pressure Liquid Biological Psychiatry Brain-derived neurotrophic factor biology Depression Endocrine and Autonomic Systems Brain-Derived Neurotrophic Factor beta-Endorphin Anandamide Amides Endocannabinoid system Bicycling Psychiatry and Mental health Hematocrit nervous system chemistry Ethanolamines biology.protein Antidepressant lipids (amino acids peptides and proteins) Psychology Endocannabinoids Neurotrophin |
| Zdroj: | Psychoneuroendocrinology (2012). info:cnr-pdr/source/autori:Heyman E, Gamelin FX, Goekint M, Piscitelli F, Roelands B, Leclair E, Di Marzo V, Meeusen R/titolo:Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression/doi:/rivista:Psychoneuroendocrinology/anno:2012/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| ISSN: | 0306-4530 |
| DOI: | 10.1016/j.psyneuen.2011.09.017 |
| Popis: | The endocannabinoid system is known to have positive effects on depression partly through its actions on neurotrophins, such as Brain-Derived Neurotrophic Factor (BDNF). As BDNF is also considered the major candidate molecule for exercise-induced brain plasticity, we hypothesized that the endocannabinoid system represents a crucial signaling system mediating the beneficial antidepressant effects of exercise. Here we investigated, in 11 healthy trained male cyclists, the effects of an intense exercise (60 min at 55% followed by 30 min at 75% W(max)) on plasma levels of endocannabinoids (anandamide, AEA and 2-arachidonoylglycerol, 2-AG) and their possible link with serum BDNF. AEA levels increased during exercise and the 15 min recovery (P0.001), whereas 2-AG concentrations remained stable. BDNF levels increased significantly during exercise and then decreased during the 15 min of recovery (P0.01). Noteworthy, AEA and BDNF concentrations were positively correlated at the end of exercise and after the 15 min recovery (r0.66, P0.05), suggesting that AEA increment during exercise might be one of the factors involved in exercise-induced increase in peripheral BDNF levels and that AEA high levels during recovery might delay the return of BDNF to basal levels. AEA production during exercise might be triggered by cortisol since we found positive correlations between these two compounds and because corticosteroids are known to stimulate endocannabinoid biosynthesis. These findings provide evidence in humans that acute exercise represents a physiological stressor able to increase peripheral levels of AEA and that BDNF might be a mechanism by which AEA influences the neuroplastic and antidepressant effects of exercise. |
| Databáze: | OpenAIRE |
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