Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion
| Autor: | Mahesh Attimarad, Ibrahim A. Alhaider, Nagesh Gangadhar, Katharigatta N. Venugopala, Saminathan Srinivasan, Afzal Haq Asif, Anroop B. Nair, Bander E. Al-Dhubiab, Sree Harsha |
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| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
education.field_of_study Drug Design Development and Therapy food.ingredient Kinetic model Chemistry Population Pharmaceutical Science Nanoparticle Nanotechnology Gelatin food Tolerability Nano spray dryer Drug Discovery medicine Mucoadhesion Vildagliptin Food science education medicine.drug |
| Zdroj: | Drug Design, Development and Therapy. :273 |
| ISSN: | 1177-8881 |
| DOI: | 10.2147/dddt.s66654 |
| Popis: | Sree N Harsha,1 Bander E Aldhubiab,1 Anroop B Nair,1 Ibrahim Abdulrahman Alhaider,1 Mahesh Attimarad,1 Katharigatta N Venugopala,1 SaminathanSrinivasan,2 Nagesh Gangadhar,2 Afzal Haq Asif3 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; 2Department of Pharmaceutics, East Point College of Pharmacy, Bangalore, India; 3Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia Abstract: Diabetes is considered one of the main threats to global public health in this era. It is increasing rapidly in every part of the world; the prevalence of the disease will grow to the point where 366million people will be affected by 2030. The prevalence of diabetes mellitus (DM) in the Saudi population is high, and the majority of patients suffer from type 2DM. Marketed oral antidiabetic drugs have indicated poor tolerability during chronic treatments, and this contributes to the moderately large proportion of type 2DM patients that remain inadequately managed. Vildagliptin nanospheres were prepared with aminated gelatin using a spray-drying method; narrow particle-size distribution was seen at 445nm. The angle of repose was found to be &theta |
| Databáze: | OpenAIRE |
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