SOME STUDIES ON TRANSAMINATION WITH OXALOACETATE

Autor:	M. Sukumaran, G. Y. N. Iyer
Rok vydání:	1959
Předmět:	Alanine chemistry.chemical_classification biology Decarboxylation Transamination General Medicine Transaminase Pyruvate carboxylase Oxaloacetate decarboxylase chemistry Biochemistry Gluconeogenesis biology.protein Citrate synthase
Zdroj:	Canadian Journal of Biochemistry and Physiology. 37:1517-1524
ISSN:	0576-5544
DOI:	10.1139/o59-169
Popis:	The formation of alanine in the transamination of α-amino-n-butyrate and glutamate with oxaloacetate in presence of liver homogenates has been studied. It could be quantitatively explained in terms of pyruvate formed by the decarboxylation of oxaloacetate and subsequent transamination. Pyruvate at high concentrations was found to have an inhibitory effect on the α-aminobutyric–pyruvic transamination. The transaminase activity of the homogenate with respect to the glutamic–oxaloacetic system was very marked whereas it was negligible in the case of the α-aminobutyric–oxaloacetic system. In the light of these findings the relative yields of alanine from the two systems are correlated.
Databáze:	OpenAIRE
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