[3H]-saxitoxinol metabolism and elimination in the rat
| Autor: | Robert W. Wannemacher, Syed M. Naseem, Harry B. Hines |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Urine Biology Toxicology Tritium High-performance liquid chromatography Excretion chemistry.chemical_compound Feces Internal medicine medicine Animals Paralytic shellfish poisoning Chromatography High Pressure Liquid Saxitoxin Poisoning Metabolism medicine.disease Rats Inbred F344 Rats Endocrinology chemistry |
| Zdroj: | Toxicon : official journal of the International Society on Toxinology. 31(7) |
| ISSN: | 0041-0101 |
| Popis: | Tritiated saxitoxinol was used to obtain preliminary information on saxitoxin metabolism in the rat. Sublethal doses of tritiated saxitoxinol (18.9-microCi/kg; 3.8 micrograms/kg) were injected i.v. into each of six rats. Urine and fecal samples were collected up to 144 hr post-injection. Within 4 hr, 60% of injected radioactivity was excreted in urine. No radioactivity was found in feces. High performance liquid chromatography analyses of urine showed that saxitoxinol was not metabolized by the rats. |
| Databáze: | OpenAIRE |
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