Disease progression in Parkinson‘s disease patients with subjective cognitive complaint
| Autor: | Yi-Min Sun, Feng-Tao Liu, Yi-Lin Tang, Yun Fan, Zhi-Heng Xu, Linlin Han, Xiaoniu Liang, Lan Wang, Wen-Bo Yu, Meng-Wei Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Parkinson's disease Excessive daytime sleepiness Neurosciences. Biological psychiatry. Neuropsychiatry Disease Diagnostic Self Evaluation Quality of life Internal medicine medicine Humans Cognitive Dysfunction Longitudinal Studies RC346-429 Depression (differential diagnoses) Aged Depression business.industry General Neuroscience Disease progression Beck Depression Inventory Parkinson Disease Cognition Middle Aged medicine.disease stomatognathic diseases Disease Progression Quality of Life Female Neurology. Diseases of the nervous system Neurology (clinical) medicine.symptom business RC321-571 Research Article |
| Zdroj: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, Vol 8, Iss 10, Pp 2096-2104 (2021) |
| ISSN: | 2328-9503 |
| DOI: | 10.1002/acn3.51461 |
| Popis: | Objective Little is known about the disease progression of Parkinson's disease patients with subjective cognitive complaint (PD‐SCC). This longitudinal cohort study aims to compare the progression of clinical features and quality of life (QoL) in PD patients with normal cognition (NC), SCC, and mild cognitive impairment (MCI). Methods A total of 383 PD patients were enrolled, including 189 PD‐NC patients, 59 PD‐SCC patients, and 135 PD‐MCI patients, with 1–7 years of follow‐up. Linear mixed models were applied to evaluate longitudinal changes in motor symptoms, nonmotor features (cognitive impairment, depression, and excessive daytime sleepiness), and QoL in PD. Results At baseline, PD‐SCC patients had lower Beck Depression Inventory (BDI) scores and Parkinson's Disease Questionnaire‐39 (PDQ‐39) scores than PD‐NC patients (all p |
| Databáze: | OpenAIRE |
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