Stem cell transplantation from a haploidentical donor versus a genoidentical sister for adult male patients with acute myelogenous leukemia in first remission: A retrospective study from the acute leukemia working party of the European Society for Blood and Marrow Transplantation

Autor: Myriam Labopin, Gérard Socié, Fabio Ciceri, Didier Blaise, Jean Bourhis, Marco R. de Groot, Mohamad Mohty, Arnon Nagler, Emmanuelle Polge, Gorin Nc
Přispěvatelé: Gorin, N. -C., Labopin, M., Blaise, D., de Groot, M., Socie, G., Bourhis, J. H., Ciceri, F., Polge, E., Nagler, A., Mohty, M., Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Oncology
Male
Cancer Research
IMPACT
Graft vs Host Disease
DISEASE
0302 clinical medicine
Bone Marrow
POSTTRANSPLANTATION CYCLOPHOSPHAMIDE
030212 general & internal medicine
ComputingMilieux_MISCELLANEOUS
Acute leukemia
OUTCOMES
RECIPIENT SEX
Hazard ratio
Remission Induction
Hematopoietic Stem Cell Transplantation
Myeloid leukemia
Middle Aged
matched sibling donors
Prognosis
Tissue Donors
Survival Rate
Leukemia
INTERMEDIATE
Leukemia
Myeloid
Acute
030220 oncology & carcinogenesis
SURVIVAL
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
medicine.drug
Adult
medicine.medical_specialty
endocrine system
Allogeneic transplantation
haploidentical donors
Cyclophosphamide
Adolescent
ACUTE MYELOID-LEUKEMIA
acute myeloid leukemia
stem cell transplantation
Risk Assessment
03 medical and health sciences
Young Adult
Internal medicine
medicine
Humans
Transplantation
Homologous
Aged
Retrospective Studies
business.industry
Siblings
Retrospective cohort study
medicine.disease
Transplantation
REGISTRY
Transplantation
Haploidentical
business
Follow-Up Studies
Zdroj: Cancer
Cancer, Wiley, 2019, 126 (5), pp.1004-1015. ⟨10.1002/cncr.32629⟩
Cancer, 126(5), 1004-1015. Wiley
Cancer, 2019, 126 (5), pp.1004-1015. ⟨10.1002/cncr.32629⟩
ISSN: 0008-543X
1097-0142
DOI: 10.1002/cncr.32629⟩
Popis: Background: In adult patients with acute myeloid leukemia (AML), a matched sibling donor (MSD) is considered the first choice for an allogeneic transplantation. However, a female donor for a male recipient is a poor prognostic factor. The authors compared haploidentical (HAPLO) donors with female MSDs. Methods: In total, 834 men underwent allogenic transplantation from a female MSD, and 232 men underwent allogenic transplantation from a HAPLO donor. Of these, 86% of HAPLO recipients and 3% of MSD recipients received graft-versus-host disease (GVHD) prophylaxis posttransplantation with high-dose cyclophosphamide. A significant qualitative interaction was observed between donor type and cytogenetics, Therefore, the analyses were stratified on cytogenetics. Results: Of the men with intermediate-risk AML, 638 received transplantation from a female MSD, and 160 received transplantation from a HAPLO donor. In multivariate analysis, poor risk factors were a HAPLO donor versus an MSD for nonrelapse mortality (hazard ratio [HR], 1.7; P=.02) and patient age for nonrelapse mortality and overall survival (HR, 1.22 [P=.02] and 1.15 [P=.02], respectively). HAPLO transplantation resulted in less chronic GVHD (HR, 0.43; P 
Databáze: OpenAIRE
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