Analysis of Gene Candidate SNP and Ancestral Origin Associated to Obesity and Postoperative Weight Loss in a Cohort of Obese Patients Undergoing RYGB
| Autor: | Eduardo Vidrio, Pablo León, Maureen Mosti, Jeny Flores-Morales, Gabriela Elisa Mercado-Celis, Donaji Rodriguez, Miguel F. Herrera, Hugo Sánchez-Aguilar, David Velázquez-Fernández, Diana Clavellina-Gaytán, Ramón Vidrio |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Gastric Bypass 030209 endocrinology & metabolism Single-nucleotide polymorphism Type 2 diabetes Gastroenterology Polymorphism Single Nucleotide Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Weight loss Internal medicine Weight Loss medicine SNP Humans Genetic Predisposition to Disease Postoperative Period Mexico Aged Nutrition and Dietetics business.industry Hispanic or Latino Middle Aged medicine.disease Obesity Surgery Obesity Morbid 030104 developmental biology Diabetes Mellitus Type 2 Cohort Female medicine.symptom business Body mass index GNB3 |
| Zdroj: | Obesity surgery. 27(6) |
| ISSN: | 1708-0428 |
| Popis: | Obesity is the result of a complex interaction between multiple genetic traits and psychological, behavioral, nutritional and environmental factors. The aims of the study were (a) to comparatively evaluate the presence of 20 candidate gene single nucleotide polymorphisms (SNPs) in morbidly obese patients, (2) their association to comorbid conditions and (3) their impact on weight loss after a Roux-en-Y gastric bypass (RYGB). Two hundred forty-nine patients were eligible for this study. Clinical, anthropometric, biochemical and demographic variables were analyzed. Body mass index (BMI) and composition were assessed by bioelectrical impedance. Twenty SNPs were included for analysis. There were 168 Mexican mestizos (67.5 %) and 81 (32.5 %) patients with other ancestral origin. One hundred fifty-nine (64.1 %) were females. Mean ± SD age of the general cohort was 41.1 ± 11.3 years (17–71). Preoperative mean ± SD BMI was 42.5 ± 6.5 kg/m2. There were no significant differences between mestizo and non-mestizo for most SNPs except for IFI, LIPC, and ST8SIA2. FTO (OR = 1.71; CI95 % = 1.14–2.57; p = 0.008) and APOB (OR = 0.31; CI95 % = 0.14–0.72; p = 0.004) result is statistically associated to high blood pressure and FTO (OR = 2.0; CI95 % = 1.3–3.1; p = 0.001), GNB3 (OR = 2.69; CI95 % = 1.0–7.2; p = 0.04), IFI30 (OR = 2.0; CI95 % = 1.16–3.6; p = 0.01), and MC4R (OR = 1.81; CI95 % = 1.13–2.9; p = 0.01) to type 2 diabetes (T2D). Based on ANOVA analysis, POMC (rs1042571) was the SNP most significantly associated to a higher weight loss after RYGB. Obese patients have similar SNP frequencies. Several SNP results are statistically associated to high blood pressure and T2D. POMC was significantly associated to a higher surgically induced weight loss. |
| Databáze: | OpenAIRE |
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