The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns
| Autor: | Jochen Kinter, Martin Steuble, K. Fink-Widmer, Peter Sonderegger, G. Hintsch, Virginia Meskenaite, Andreas Zurlinden |
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| Přispěvatelé: | University of Zurich, Hintsch, G |
| Rok vydání: | 2002 |
| Předmět: |
Central Nervous System
Male Protein family Immunoelectron microscopy Molecular Sequence Data 2804 Cellular and Molecular Neuroscience Synaptic Membranes Biology Neurotransmission Synaptic Transmission 1307 Cell Biology Cellular and Molecular Neuroscience Mice Sequence Homology Nucleic Acid 10019 Department of Biochemistry 1312 Molecular Biology Calsyntenin Animals Humans RNA Messenger Molecular Biology Cells Cultured Neurons Chromosomes Human Pair 12 Sequence Homology Amino Acid Calcium-Binding Proteins Membrane Proteins Cell Biology Immunohistochemistry Cell biology Mice Inbred C57BL Microscopy Electron Membrane protein Chromosomes Human Pair 1 Synaptic plasticity Excitatory postsynaptic potential 570 Life sciences biology Chromosomes Human Pair 3 Rabbits Postsynaptic density |
| Zdroj: | Molecular and cellular neurosciences. 21(3) |
| ISSN: | 1044-7431 |
| Popis: | We have identified two novel postsynaptic membrane proteins that are highly similar to calsyntenin-1 in their extracellular parts but vary considerably in their cytoplasmic segment. Calsyntenin-1 has recently been identified in our lab as a postsynaptic membrane protein with a highly acidic cytoplasmic segment with putative Ca(2+)-binding capacity (Vogt et al., 2001, Mol. Cell. Neurosci. 17: 151-166). Based on their structural similarity to calsyntenin-1, we have called the novel proteins calsyntenin-2 and -3, respectively. By immunoelectron microscopy, the calsyntenin protein family was localized in the postsynaptic membrane of excitatory central nervous system (CNS) synapses. In situ hybridization analysis revealed that calsyntenin-1 was abundant in most neurons of the CNS with relatively little variation in its expression level. Calsyntenin-2 and -3 expressions varied much more with highest levels in GABAergic neurons. Based on their distinct expression patterns and the differences in their cytoplasmic segments, we suggest a cell-type-specific functional role for the three calsyntenins in excitatory synaptic transmission. |
| Databáze: | OpenAIRE |
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