Estrogen Action: Induction of the Synthesis of a Specific Protein (IP) in the Myometrium, the Stroma and the Luminal Epithelium of the Rat Uterus
| Autor: | N. Dupont-Mairesse, Paul Galand |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Stromal cell medicine.drug_class Uterus Muscle Proteins Biology Endocrinology Stroma Leucine Internal medicine medicine Animals Castration Estradiol Ovary Myometrium Epithelium Rats medicine.anatomical_structure Organ Specificity Estrogen Rat uterus Electrophoresis Polyacrylamide Gel Female hormones hormone substitutes and hormone antagonists Homogenization (biology) |
| Zdroj: | Endocrinology. 96:1587-1591 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-96-6-1587 |
| Popis: | The effect of estrogen on the synthesis of a specific uterine protein (estrogen-induced protein = IP) was investigated at the level of the epithelial, stromal and myometrial tissue fractions. For measuring IP induction, the procedure of Katzenellenbogen and Gorski was followed exactly (involving co-electrophoresis of soluble protein extracts from 3H-labeled estrogen treated uteri and l4C-labeled controls) except for the fact that the uteri were fractionated into their three main tissue components before homogenization. The results show that induction of IP synthesis by estradiol takes place in the three tissue fractions considered. This is consistent with hypotheses assuming a key function for IP in the development of the full estrogenic response in the uterus. (Endocrinology 96: 1587, 1975) |
| Databáze: | OpenAIRE |
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