The protective efficacy of magnolol in hind limb ischemia-reperfusion injury
| Autor: | Tsung-Ying Chen, E-Jian Lee, Hung-Yi Chen, I-Chuan Chuang, Tian Shung Wu, Yu-Chang Hung |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Ischemia Drug Evaluation Preclinical Pharmaceutical Science Hematocrit Pharmacology Nitric Oxide Lignans Body Temperature Rats Sprague-Dawley chemistry.chemical_compound Malondialdehyde Drug Discovery medicine Animals Peroxidase medicine.diagnostic_test biology Plant Extracts Anti-Inflammatory Agents Non-Steroidal Biphenyl Compounds medicine.disease Free radical scavenger biology.organism_classification Magnolol Hindlimb Rats Magnolia officinalis Complementary and alternative medicine chemistry Magnolia Regional Blood Flow Anesthesia Reperfusion Injury Molecular Medicine Arterial blood Reperfusion injury Phytotherapy |
| Zdroj: | Phytomedicine : international journal of phytotherapy and phytopharmacology. 16(10) |
| ISSN: | 1618-095X |
| Popis: | We investigated the protective effects of magnolol, an active antioxidant and free radical scavenger extracted from Magnolia officinalis, in a hind limb ischemic-reperfusion animal model. Adult male Sprague-Dawley rats were subjected to hind limb ischemic insult for 2 hours and were intravenously treated with magnolol at 0.01 mg/kg (n=8), 0.3 mg/kg (n=8) mg/kg or 1 mg/kg (n=8) mg/kg, or vehicle (n=8). At 24 h post-insult, the levels of nitrite/nitrate (NOX), malondialdehyde (MDA) and myeloperoxidase (MPO), as well as the degree of muscle damage, were assessed. Relative to controls, animals treated with magnolol (0.3 and 1 mg/kg) had attenuated muscular inflammation, edema and damage. Magnolol (0.3-1 mg/kg) also effectively reduced postischemic rises in the MDA, NOx and MPO levels (p |
| Databáze: | OpenAIRE |
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