Brain resting-state networks in adolescents with high-functioning autism: Analysis of spatial connectivity and temporal neurodynamics

Autor: Marc P. H. Hendriks, Frans M. J. Willems, Svitlana Zinger, Walter H. Backes, Roy P. C. Kessels, Albert P. Aldenkamp, Evelien M. Barendse, Antoine Bernas, Paul A. M. Hofman, Jacobus F.A. Jansen
Přispěvatelé: RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen, Beeldvorming, MUMC+: DA BV Klinisch Fysicus (9), MUMC+: DA BV Medisch Specialisten Radiologie (9), Video Coding & Architectures, Signal Processing Systems, Biomedical Diagnostics Lab
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
resting‐state brain connectivity
Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1]
Connectome/methods
Emotions
CHILDREN
Brain mapping
Autism Spectrum Disorder/physiopathology
Magnetic Resonance Imaging/methods
Behavioral Neuroscience
Cognition
0302 clinical medicine
Cognition/physiology
Original Research
Brain Mapping
medicine.diagnostic_test
05 social sciences
high‐functioning autism
Nerve Net/diagnostic imaging
Magnetic Resonance Imaging
Temporal Lobe
high-functioning autism
Autism spectrum disorder
Connectome
Granger causality
functional MRI
Female
Psychology
MRI
Adolescent
temporal neurodynamics
Prefrontal Cortex
autism spectrum disorder
resting-state brain connectivity
SPECTRUM DISORDERS
GRANGER CAUSALITY ANALYSIS
behavioral disciplines and activities
050105 experimental psychology
Temporal Lobe/diagnostic imaging
Temporal lobe
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
WORKING-MEMORY
Spatio-Temporal Analysis
mental disorders
Brain Mapping/methods
medicine
Humans
Prefrontal Cortex/diagnostic imaging
0501 psychology and cognitive sciences
Neuro- en revalidatiepsychologie
Resting state fMRI
INDEPENDENT COMPONENT ANALYSIS
IDENTIFICATION
Neuropsychology and rehabilitation psychology
Plasticity and Memory [DI-BCB_DCC_Theme 3]
ADULTS
autism spectrum disorder
functional MRI
Granger causality
high-functioning autism
independent component analysis
resting-state brain connectivity
temporal neurodynamics
medicine.disease
High-functioning autism
Emotions/physiology
PATTERNS
Autism
INFERENCE
Nerve Net
Functional magnetic resonance imaging
Neuroscience
030217 neurology & neurosurgery
Zdroj: Brain and Behavior, 8(2):e00878. John Wiley & Sons Inc.
Brain and Behavior, 8, 2, pp.
Brain and Behavior, 8,
Brain and Behavior, 8(2):e00878. Wiley
Brain and Behavior
ISSN: 2162-3279
Popis: Contains fulltext : 183400.pdf (Publisher’s version ) (Open Access) Introduction: Autism spectrum disorder (ASD) is mainly characterized by functional and communication impairments as well as restrictive and repetitive behavior. The leading hypothesis for the neural basis of autism postulates globally abnormal brain connectivity, which can be assessed using functional magnetic resonance imaging (fMRI). Even in the absence of a task, the brain exhibits a high degree of functional connectivity, known as intrinsic, or resting-state, connectivity. Global default connectivity in individuals with autism versus controls is not well characterized, especially for a high-functioning young population. The aim of this study is to test whether high-functioning adolescents with ASD (HFA) have an abnormal resting-state functional connectivity. Materials and Methods: We performed spatial and temporal analyses on resting-state networks (RSNs) in 13 HFA adolescents and 13 IQ- and age-matched controls. For the spatial analysis, we used probabilistic independent component analysis (ICA) and a permutation statistical method to reveal the RSN differences between the groups. For the temporal analysis, we applied Granger causality to find differences in temporal neurodynamics. Results: Controls and HFA display very similar patterns and strengths of resting-state connectivity. We do not find any significant differences between HFA adolescents and controls in the spatial resting-state connectivity. However, in the temporal dynamics of this connectivity, we did find differences in the causal effect properties of RSNs originating in temporal and prefrontal cortices. Conclusion: The results show a difference between HFA and controls in the temporal neurodynamics from the ventral attention network to the salience-executive network: a pathway involving cognitive, executive, and emotion-related cortices. We hypothesized that this weaker dynamic pathway is due to a subtle trigger challenging the cognitive state prior to the resting state. 10 p.
Databáze: OpenAIRE
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