Micronutrient-Fortified Rice Can Increase Hookworm Infection Risk
| Autor: | Chhoun Chamnan, Maiza Campos Ponce, Jacques Berger, Michiel R. de Boer, Brechje de Gier, Marjoleine A. Dijkhuizen, Marion Fiorentino, Katja Polman, Megan Parker, Kurt Burja, Kuong Khov, Marlene Perignon, Frank T. Wieringa |
|---|---|
| Přispěvatelé: | Health & Life, Infectious Diseases, Methodology and Applied Biostatistics, Science and Society, Nutrition and Health, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Ancylostomatoidea Male Veterinary medicine lcsh:Medicine medicine.disease_cause law.invention Feces 0302 clinical medicine Randomized controlled trial law Prevalence Medicine 030212 general & internal medicine Longitudinal Studies Micronutrients Intestinal Diseases Parasitic lcsh:Science Child Non-U.S. Gov't ComputingMilieux_MISCELLANEOUS 2. Zero hunger Multidisciplinary biology Research Support Non-U.S. Gov't Fortified Micronutrient Clinical Trial 3. Good health Parasitic Food Fortified Randomized Controlled Trial Female Iron Dietary Research Article Iron Fortification education Dietary Non-P.H.S Intestinal parasite Enzyme-Linked Immunosorbent Assay Placebo Research Support 03 medical and health sciences Double-Blind Method Environmental health parasitic diseases Journal Article Animals Humans SDG 2 - Zero Hunger Hookworm infection 030109 nutrition & dietetics business.industry lcsh:R Oryza biology.organism_classification Placebo Effect Intestinal Diseases Food lcsh:Q [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie U.S. Gov't Calprotectin business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Leukocyte L1 Antigen Complex Research Support U.S. Gov't Non-P.H.S |
| Zdroj: | PLoS ONE, 11(1):e0145351. Public Library of Science PLoS ONE PLoS ONE, Public Library of Science, 2016, 11 (1), pp.e0145351. ⟨10.1371/journal.pone.0145351⟩ PLoS ONE, Vol 11, Iss 1, p e0145351 (2016) de Gier, B, Campos Ponce, M, Perignon, M, Fiorentino, M, Khov, K, Chamnan, C, de Boer, M R, Parker, M E, Burja, K, Dijkhuizen, M A, Berger, J, Polman, K & Wieringa, F T 2016, ' Micronutrient-fortified rice can increase hookworm infection risk : A cluster randomized trial ', P L o S One, vol. 11, no. 1, e0145351 . https://doi.org/10.1371/journal.pone.0145351 de Gier, B, Campos, M, Perignon, M, Fiorentino, M, Khov, K, Chamnan, C, de Boer, M R, Parker, M E, Burja, K, Dijkhuizen, M A, Berger, J, Polman, K & Wieringa, F T 2016, ' Micronutrient-Fortified Rice Can Increase Hookworm Infection Risk : A Cluster Randomized Trial ', PLoS ONE, vol. 11, no. 1, e0145351 . https://doi.org/10.1371/journal.pone.0145351 |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: Fortification of staple foods is considered an effective and safe strategy to combat micronutrient deficiencies, thereby improving health. While improving micronutrient status might be expected to have positive effects on immunity, some studies have reported increases in infections or inflammation after iron supplementation.OBJECTIVE: To study effects of micronutrient-fortified rice on hookworm infection in Cambodian schoolchildren.METHODS: A double-blinded, cluster-randomized trial was conducted in 16 Cambodian primary schools partaking in the World Food Program school meal program. Three types of multi-micronutrient fortified rice were tested against placebo rice within the school meal program: UltraRice_original, UltraRice_improved and NutriRice. Four schools were randomly assigned to each study group (placebo n = 492, UltraRice_original n = 479, UltraRice_improved n = 500, NutriRice n = 506). Intestinal parasite infection was measured in fecal samples by Kato-Katz method at baseline and after three and seven months. In a subgroup (N = 330), fecal calprotectin was measured by ELISA as a marker for intestinal inflammation.RESULTS: Baseline prevalence of hookworm infection was 18.6%, but differed considerably among schools (range 0%- 48.1%).Micronutrient-fortified rice significantly increased risk of new hookworm infection. This effect was modified by baseline hookworm prevalence at the school; hookworm infection risk was increased by all three types of fortified rice in schools where baseline prevalence was high (>15%), and only by UltraRice_original in schools with low baseline prevalence. Neither hookworm infection nor fortified rice was related to fecal calprotectin.CONCLUSIONS: Consumption of rice fortified with micronutrients can increase hookworm prevalence, especially in environments with high infection pressure. When considering fortification of staple foods, a careful risk-benefit analysis is warranted, taking into account severity of micronutrient deficiencies and local prevalence of parasitic infections.TRIAL REGISTRATION: ClinicalTrials.gov NCT01706419. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|