Tumor Growth Suppression With Novel Intra-arterial Chemotherapy Using Epirubicin-entrapped Water-in-oil-in-water Emulsion In Vivo
| Autor: | Ryouji Mizumachi, Yuuya Ono, Tomoyuki Hisa, Yoshitaka Furuya, Novriana Dewi, Hiroyuki Takahashi, Jun Nakajima, Tadao Nakashima, Masashi Nagata, Minoru Ono, Yasumasa Nonaka, Toshimitsu Terao, Yasuyuki Morishita, Takashi Fujino, Masashi Yanagawa, Koji Seguchi, Mitsuteru Fujihara, Masazumi Eriguchi, Kazuhiko Arimori, Kazuhiro Kakimi, Takeshi Nagasaki, Takumichi Sugihara, Hironobu Yanagie, Shushi Higashi, Yuuji Murata, Ichiro Ikushima, Takashi Imagawa |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Carcinoma Hepatocellular food.ingredient medicine.medical_treatment Pharmacology Poppy seed Endocytosis General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine food In vivo medicine Animals Humans Epirubicin Chemotherapy Chemistry Liver Neoplasms Water medicine.disease 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer cell Toxicity Emulsions Rabbits Research Article medicine.drug |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 0258-851X |
| DOI: | 10.21873/invivo.12252 |
| Popis: | Background/aim A mixture of anticancer agents and iodized poppy seed oil (IPSO) has been widely used for intra-arterial chemotherapy of hepatocellular carcinoma. However, the anticancer agents can easily separate from IPSO, so the therapeutic potential is limited. We developed epirubicin-entrapped water-in-oil-in-water emulsion (WOW-Epi) using a double-membrane emulsification technique. Materials and methods We delivered WOW-Epi through a hepatic arterial injection to VX2 hepatic tumor rabbit model (1.2 mg/kg). Results VX2 tumor growth was selectively suppressed in the WOW-Epi-treated group compared with the control treated groups. The accumulation of WOW in nearby cancer cells was confirmed via electron-microscopy. Endocytosis seemed to be the mechanism underlying the uptake of WOW. Conclusion WOW-Epi led to tumour growth suppression in vivo. WOW does not cause toxicity to arterial vessels. WOW-Epi will be hopefully used for repeated intra-arterial chemotherapy to HCC patients in the near future. |
| Databáze: | OpenAIRE |
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