Midlife gene expressions identify modulators of aging through dietary interventions
| Autor: | Li Zhu, Zhen Yan, Jing-Dong J. Han, Haiyang Chen, Jinbo Wang, Huasheng Xiao, Matt Kaeberlein, Jialiang Huang, Xun Huang, Bing Zhou, Lei Hou, Yong（刘勇） Liu, Shoufeng Li, Liu（杨柳） Yang, Christopher D. Green |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Aging Longevity Peroxisome Proliferation Mitochondria Liver Mice Microscopy Electron Transmission RNA interference Gene expression Peroxisomes Animals Cluster Analysis Caenorhabditis elegans Gene Oligonucleotide Array Sequence Analysis Genetics Multidisciplinary biology Gene Expression Profiling Hydrogen Peroxide Peroxisome biology.organism_classification Phenotype Diet Gene expression profiling Mice Inbred C57BL Drosophila melanogaster PNAS Plus Female RNA Interference Energy Metabolism Reactive Oxygen Species |
| Popis: | Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. We found that pathways transcriptionally correlated with diet-modulated lifespan and physiological changes were enriched for lifespan-modifying genes. Intriguingly, mitochondrial gene expression correlated with lifespan and anticorrelated with aging-related pathological changes, whereas peroxisomal gene expression showed an opposite trend. Both organelles produce reactive oxygen species, a proposed causative factor of aging. This finding implicates a contribution of peroxisome to aging. Consistent with this hypothesis, lowering the expression levels of peroxisome proliferation genes decreased the cellular peroxide levels and extended the lifespan of Drosophila melanogaster and Caenorhabditis elegans . These findings show that transcriptional changes resulting from dietary interventions can effectively reflect causal factors in aging and identify previously unknown or under-appreciated longevity pathways, such as the peroxisome pathway. |
| Databáze: | OpenAIRE |
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