Dose-volume predictors of post-radiation primary hypothyroidism in head and neck cancer: A systematic review
| Autor: | James C.H. Chow, Ka-Man Cheung, Gavin T.C. Cheung, Anthony H.P. Tam, Jeffrey C.F. Lui, Francis K.H. Lee, Kwok-Hung Au, Wai-Tong Ng, Anne W.M. Lee, Harry H.Y. Yiu |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
endocrine system
HNC head and neck cancer Vx thyroid volume that receives x Gy of radiation dose endocrine system diseases NPC nasopharyngeal cancer R895-920 Review Article Survivorship Head and neck neoplasms Medical physics. Medical radiology. Nuclear medicine Dmean mean dose ULN upper limit of normal Hypothyroidism NTCP normal tissue complication probability 3DRT dimensional radiotherapy Radiology Nuclear Medicine and imaging VSx thyroid volume that is spared from x Gy of radiation dose RC254-282 QUANTEC Quantitative Analysis of The Normal Tissue Effects in the Clinic Radiotherapy CT computer tomography OPC oropharyngeal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens IMRT intensity modulated radiotherapy PRIMSA Preferred Reporting Items for Systematic Reviews and meta-Analyses CI confidence interval OR odds ratio Oncology ROC receiver operating curve TSH thyroid stimulating hormone hormones hormone substitutes and hormone antagonists Dmin minimum dose |
| Zdroj: | Clinical and Translational Radiation Oncology, Vol 33, Iss, Pp 83-92 (2022) Clinical and Translational Radiation Oncology |
| ISSN: | 2405-6308 |
| Popis: | Highlights • This systematic review included 29 studies (n = 4,530 patients) on dosimetric predictors of primary hypothyroidism in HNC. • Average crude incidence of primary hypothyroidism after HNC radiotherapy was 41.4%. • Thyroid Dmean and V50 were the most widely reported dosimetric predictors for hypothyroidism. • Thyroid volume is a predictor of hypothyroidism (pooled aOR 0.89 per 1 cc increment) independent of radiation dosimetry. • Thyroid gland constraints individualized for thyroid volume are crucial in HNC radiotherapy. Background and Purpose This systematic review aims to identify radiation dose-volume predictors of primary hypothyroidism after radiotherapy in patients with head and neck cancer (HNC). Materials and methods We performed a systematic literature search of Medline, EMBASE and Web of Science from database inception to July 1, 2021 for articles that discuss radiation dose-volume predictors of post-radiation primary hypothyroidism in patients with HNC. Data on the incidence, clinical risk factors and radiation dose-volume parameters were extracted. A meta-analysis was performed using the random-effects model to estimate the pooled odds ratio (OR) of thyroid volume as a predictor of the risk of post-radiation hypothyroidism, adjusted for thyroid radiation dosimetry. Results Our search identified 29 observational studies involving 4,530 patients. With median follow-up durations ranging from 1.0 to 5.3 years, the average crude incidence of post-radiation primary hypothyroidism was 41.4 % (range, 10 %–57 %). Multiple radiation dose-volume parameters were associated with post-radiation primary hypothyroidism, including the thyroid mean dose (Dmean), minimum dose, V25, V30, V35, V45, V50, V30–60, VS45 and VS60. Thyroid Dmean and V50 were the most frequently proposed dosimetric predictors. The pooled adjusted OR of thyroid volume on the risk of post-radiation primary hypothyroidism was 0.89 (95 % confidence interval, 0.85–0.93; p |
| Databáze: | OpenAIRE |
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