Dynamic single gold nanoparticle visualization by clinical intracoronary optical coherence tomography
| Autor: | Fernando Alfonso, Jie Hu, Daniel Jaque, Fernando Rivero, Emma Martín Rodríguez, Río Aguilar Torres, José García Solé, Héctor Loro Ramírez |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Materials science genetic structures General Physics and Astronomy Nanoparticle Contrast Media Metal Nanoparticles 030204 cardiovascular system & hematology 01 natural sciences General Biochemistry Genetics and Molecular Biology 010309 optics 03 medical and health sciences 0302 clinical medicine Optical coherence tomography 0103 physical sciences medicine Humans General Materials Science Medical physics Plasmon medicine.diagnostic_test Scattering General Engineering General Chemistry Coronary Vessels eye diseases Visualization Wavelength Gold nanoshells Colloidal gold sense organs Gold Tomography Optical Coherence Biomedical engineering |
| Zdroj: | Journal of biophotonics. 10(5) |
| ISSN: | 1864-0648 |
| Popis: | The potential use of Gold Nanoparticles (GNPs) as contrast agents for clinical intracoronary frequency domain Optical Coherence Tomography (OCT) is here explored. The OCT contrast enhancement caused by GNPs of different sizes and morphologies has been systematically investigated and correlated with their optical properties. Among the different GNPs commercially available with plasmon resonances close to the operating wavelength of intracoronary OCT (1.3 µm), Gold Nanoshells (GNSs) have provided the best OCT contrast due to their largest scattering cross section at this wavelength. Clinical intracoronary OCT catheters are here demonstrated to be capable of three dimensional visualization and real-time tracking of individual GNSs. Results here included open an avenue to novel application of intravascular clinical OCT in combination with GNPs, such as real time evaluation of intravascular obstructions or pressure gradients. |
| Databáze: | OpenAIRE |
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