Multivisceral resection for primary locally advanced rectal carcinoma

Autor: D A, Harris, M, Davies, M G, Lucas, P, Drew, N D, Carr, J, Beynon, N, Fenn
Rok vydání: 2010
Předmět:
Zdroj: British Journal of Surgery. 98:582-588
ISSN: 1365-2168
0007-1323
Popis: Background Pelvic multivisceral resection offers the possibility of cure in patients with locally advanced rectal cancer. This study assessed the clinical outcome and determinants of survival and local recurrence in patients undergoing multivisceral resection for clinical T4 primary rectal cancer. Methods This was a cohort study of consecutive multivisceral resections carried out in a single centre from 2000 to 2009. Determinants of local recurrence and survival were examined by means of Kaplan–Meier survival curves and Cox regression analysis. Results The study included 42 patients, with a median age of 62 (range 41–83) years, who underwent surgery with a median follow-up of 30 (range 2–102) months. Thirty-one patients had preoperative chemoradiotherapy. Seven patients had rectal resection with en bloc radical prostatectomy. The 30-day mortality rate was zero. Thirty-nine of the 42 patients had a negative circumferential resection margin. The 5-year overall survival rate for those who had complete resection was 48 per cent. Local recurrence was predicted by metastatic disease (P < 0·001) and nodal disease (P < 0·001), but not positive resection margins (P = 0·077). Conclusion An aggressive surgical strategy with complete resection is predictive of long-term survival in selected patients with T4a rectal carcinoma. With optimal treatment local recurrence is a sign of systemic disease.
Databáze: OpenAIRE
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