Serum levels of the myokine irisin in relation to metabolic and renal function
| Autor: | Denise Focke, Ulrike Lossner, Thomas Ebert, Susan Kralisch, Ingolf Bast, Juergen Kratzsch, Matthias Blüher, Joachim Beige, Matthias Anders, Mathias Fasshauer, Ulrike Wurst, David Petroff, Michael Stumvoll, J Richter, Anette Bachmann |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Renal function Enzyme-Linked Immunosorbent Assay Biology Carbohydrate metabolism Severity of Illness Index Body Mass Index Impaired glucose tolerance Endocrinology Insulin resistance Diastole Internal medicine Glucose Intolerance Myokine medicine Humans Renal Insufficiency Chronic Aged Dyslipidemias Aged 80 and over Inflammation Metabolic Syndrome General Medicine Middle Aged medicine.disease Fibronectins Cross-Sectional Studies Hypertension Multivariate Analysis Kidney Failure Chronic Female Insulin Resistance Metabolic syndrome Dyslipidemia Glomerular Filtration Rate Kidney disease |
| Zdroj: | European Journal of Endocrinology. 170:501-506 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | ObjectiveIrisin has recently been introduced as a novel myokine which reverses visceral obesity and improves glucose metabolism in mice. However, regulation of irisin in humans in relation to renal and metabolic disease has not been comprehensively studied.Design and methodsSerum irisin levels were quantified by ELISA and correlated with anthropometric and biochemical parameters of renal function, glucose and lipid metabolism, as well as inflammation, in 532 patients with stages 1–5 of chronic kidney disease (CKD).ResultsMedian serum irisin levels adjusted for age, gender, and BMI significantly decreased with increasing CKD stage and lowest concentrations were seen in patients with CKD stage 5. Furthermore, irisin concentrations were associated with facets of the metabolic syndrome including diastolic blood pressure, markers of impaired glucose tolerance, and dyslipidemia in univariate analysis. Moreover, markers of renal function, e.g. glomerular filtration rate, and insulin resistance, e.g. homeostasis model assessment of insulin resistance, remained independently associated with circulating irisin levels in robust multivariate analysis.ConclusionsWe show that irisin serum concentrations decrease with increasing CKD stage and are independently and positively predicted by renal function and insulin resistance. The physiological relevance of our findings, as well as the factors contributing to irisin regulation in humans, needs to be further defined in future experiments. |
| Databáze: | OpenAIRE |
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