AFP-producing Xp11 translocation renal cell carcinoma: Case report and review of the literature
| Autor: | Hui-Zhi Zhang, Su-Ying Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research Pathology medicine.medical_specialty Hepatoid adenocarcinoma TFE3 Chromosomal translocation urologic and male genital diseases Translocation Genetic 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Biomarkers Tumor Humans Medicine Carcinoma Renal Cell neoplasms Tumor marker business.industry digestive oral and skin physiology Rare entity medicine.disease Kidney Neoplasms digestive system diseases Treatment Outcome 030104 developmental biology Oncology 030220 oncology & carcinogenesis embryonic structures Immunohistochemistry alpha-Fetoproteins business Immunostaining |
| Zdroj: | Current Problems in Cancer. 45:100689 |
| ISSN: | 0147-0272 |
| Popis: | Alpha-fetoprotein (AFP) is a useful tumor marker for hepatocellular carcinomas and yolk sac tumors. Rare extrahepatic visceral malignancies may be associated with AFP production and those exhibiting a hepatoid differentiation by morphology and immunohistochemical are classified as hepatoid adenocarcinoma. Renal cell carcinoma (RCC) producing AFP is a rare entity. To date, only one case of AFP-producing Xp11 translocation RCC has been reported. We reported another case of Xp11 translocation RCC, in which the tumor cells displayed strong immunostaining for AFP, HepPar1, and GPC-3. Additionally, the other published cases are reviewed. |
| Databáze: | OpenAIRE |
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