High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients
| Autor: | Jérôme Couturier, Bernard Asselain, Corine Plancher, Jean Paul Thiery, David Gentien, Océane Anezo, Benoit Albaud, Laurence Desjardins, Sergio Roman-Roman, Cécile Laurent, Emmanuel Barillot, Audrey Rapinat, Xavier Sastre-Garau, Philippe Hupé, Fabien Valet, Cécile Reyes, Licia Silveri, Sophie Piperno-Neumann, Nathalie Planque, Selma Maacha, Simon Saule |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Uveal Neoplasms Cancer Research Pathology medicine.medical_specialty Enucleation Gene Expression Chick Embryo Protein tyrosine phosphatase Eye Enucleation Metastasis Gene expression Biomarkers Tumor Animals Humans Medicine Melanoma business.industry Liver Neoplasms Cancer Cell migration Middle Aged medicine.disease Neoplasm Proteins Survival Rate Oncology Female Protein Tyrosine Phosphatases business Chromosomes Human Pair 8 Comparative genomic hybridization |
| Zdroj: | Cancer Research. 71:666-674 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | A high percentage of uveal melanoma patients develop metastatic tumors predominantly in the liver. We studied the molecular profiles derived from gene expression microarrays and comparative genomic hybridization microarrays, to identify genes associated with metastasis in this aggressive cancer. We compared 28 uveal melanomas from patients who developed liver metastases within three years of enucleation with 35 tumors from patients without metastases or who developed metastases more than 3 years after enucleation. Protein tyrosine phosphatase type IV A member 3 (PTP4A3/PRL3), was identified as a strong predictor of metastasis occurrence. We demonstrated that the differential expression of this gene, which maps to 8q24.3, was not merely a consequence of 8q chromosome overrepresentation. PTP4A3 overexpression in uveal melanoma cell lines significantly increased cell migration and invasiveness in vivo, suggesting a direct role for this protein in metastasis. Our findings suggest that PTP4A3 or its cellular substrates could constitute attractive therapeutic targets to treat metastatic uveal melanomas. Cancer Res; 71(3); 666–74. ©2010 AACR. |
| Databáze: | OpenAIRE |
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