Prolonged analgesic effect of PLGA-encapsulated bee venom on formalin-induced pain in rats
| Autor: | Sung-Keel Kang, Kang-Min Lee, Beom-Soo Kim, Chang-Shick Yin, Dae-Hyun Hahm, Hyejung Lee, Injae Jeong, Insop Shim |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Analgesic Pain Pharmaceutical Science Biocompatible Materials Venom macromolecular substances Zusanli complex mixtures Rats Sprague-Dawley Subcutaneous injection Drug Delivery Systems Polylactic Acid-Polyglycolic Acid Copolymer Edema Acupuncture Animals Medicine Lactic Acid Particle Size Pain Measurement business.industry Bee Venoms technology industry and agriculture Rats Acupuncture point Delayed-Action Preparations Anesthesia Nanoparticles medicine.symptom business Acupuncture Points Polyglycolic Acid |
| Zdroj: | International Journal of Pharmaceutics. 380:62-66 |
| ISSN: | 0378-5173 |
| Popis: | To enhance the medicinal activity of bee venom (BV) acupuncture, bee venom was loaded into biodegradable poly(D,L-lactide-co-glycolide) nanoparticles (BV-PLGA-NPs) by a water-in-oil-in-water-emulsion/solvent-evaporation technique. Rat formalin tests were performed after subcutaneous injection of BV-PLGA-NPs to the Zusanli acupuncture point (ST36) at 0.5, 1, 2, 6, 12, 24, and 48 h before plantar injection of 2% formalin. BV-PLGA-NPs treatment showed comparable analgesic activity to typical BV acupuncture during the late phase, compared with saline-treated controls, and the analgesic effect lasted for 12h. PLGA-encapsulation was also effective in alleviating the edema induced by allergens in bee venom. These results indicate that PLGA-encapsulation provided a more prolonged effect of BV acupuncture treatment, while maintaining a comparable therapeutic effect. |
| Databáze: | OpenAIRE |
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